| Diuretic alone | Diuretic + Irbesartan | Diuretic + Ramipril | p Value | |
| Readmission for HF (%) | 6 (12.2) | 6 (11.1) | 5 (11.4) | |
| Cardiovascular death (weeks) | 1 (38) | 1 (51) | 0 | |
| Other cause of death | 2 (liver and lung cancer) | 0 | 0 | |
| Withdrawn (%) | 3 (6.0) | 3 (5.3) | 6 (13.3) | |
| QoL score | ||||
| Baseline | 20 (1.8) | 19 (2.1) | 23 (2.3) | 0.3 |
| 12 weeks | 12.9 (1.5)** | 10.8 (1.6)** | 12.7 (1.4)** | 0.9 |
| 24 weeks | 10. 9 (1.3)** | 9.6 (1.2)** | 12.9 (1.7)** | 0.8 |
| 52 weeks | 10.9 (1.3)** | 9.4 (1.3)** | 11.4 (1.4)** | 0.7 |
| 6MWT (feet/6 mins) | ||||
| Baseline | 1011 (37) | 950 (37) | 962 (42) | 0.4 |
| 12 weeks | 1055 (38) | 988 (37) | 1011 (43) | 0.2 |
| 24 weeks | 1048 (43) | 1007 (33) | 1028 (37) | 0.8 |
| Blood pressure (mean (SD)) (mm Hg) | ||||
| Baseline | 145 (23)/80 (12) | 144 (19)/82 (10) | 143 (22)/82 (10) | 0.9 |
| 4 weeks | 139 (21)/77 (10)*** | 134 (16)/76 (11)*** | 138 (21)/77 (12)*** | 0.3 |
| 8 weeks | 134 (18)/76 (13)*** | 135 (18)/76 (11)*** | 139 (20)/76 (11)*** | 0.6 |
| 12 weeks | 134 (21)/75 (12)*** | 136 (20)/76 (10)*** | 136 (18)/77 (10)*** | 0.9 |
| 24 weeks | 138 (17)/80 (9)*** | 136 (20)/76 (12)** | 137 (21)/76 (11) | 0.5 |
| 52 weeks | 138 (24)/78 (10) | 137 (21)/73 (10) | 141 (23)/76 (13) | 0.7 |
| NT-proBNP (mean (SD)) (pg/ml) | ||||
| Baseline | 566 (944) | 568 (757) | 488 (701) | 0.7 |
| 12 weeks | 390 (625) | 394 (641) | 282 (376) | 1.0 |
| 52 weeks | 334 (414) | 443 (603)** | 314 (422)* | 0.52 |
Results expressed as mean (SEM) unless otherwise stated.
*p<0.05; **p<0.01; ***p<0.001 vs baseline.
NT-proBNP, N-terminal pro-brain natriuretic peptide; QoL, quality of life score; 6MWT, 6-minute corridor walk test.