| Diuretic group | ||||
| Baseline | 12 weeks | 24 weeks | 52 weeks | |
| IVSd (cm) | 1.39 (0.04) | 1.37 (0.05) | 1.38 (0.05) | 1.34 (0.04)* |
| LVEDD (cm) | 4.90 (0.11) | 4.83 (0.11) | 4.78 (0.12) | 4.81 (0.10) |
| LVESD (cm) | 3.28 (0.12) | 3.34 (0.13) | 3.28 (0.12) | 3.30 (0.11) |
| LVEF (%) | 0.69 (0.02) | 0.66 (0.02) | 0.67 (0.02) | 0.67 (0.02) |
| LV mass (g) | 309.85 (14.27) | 290.85 (16.04) | 297.90 (15.46) | 299.52 (17.38) |
| LAD (cm) | 3.85 (0.08) | 3.76 (0.11) | 3.74 (0.10) | 3.74 (0.10) |
| E (m/s) | 0.67 (0.03) | 0.68 (0.03) | 0.70 (0.04) | 0.69 (0.03) |
| A (m/s) | 0.91 (0.03) | 0.89 (0.03) | 0.90 (0.03) | 0.94 (0.03) |
| E/A | 0.74 (0.05) | 0.77 (0.05) | 0.75 (0.04) | 0.73 (0.04) |
| IVRT (ms) | 117.93 (6.00) | 121.49 (5.62) | 114.08 (4.02) | 113.73 (3.44) |
| Sm (cm/s) | 4.57 (0.22) | 4.55 (0.20) | 4.64 (0.21) | 4.89 (0.21)* |
| Em (cm/s) | 3.95 (0.31) | 4.14 (0.27) | 4.20 (0.29) | 4.24 (0.27) |
| E/Em | 24.83 (5.64) | 20.40 (3.03) | 27.26 (8.74) | 19.61 (2.06) |
| Diuretic + Irbesartan group | ||||
| Baseline | 12 weeks | 24 weeks | 52 weeks | |
| IVSd (cm) | 1.41 (0.04) | 1.34 (0.04) | 1.29 (0.04)* | 1.28 (0.04)* |
| LVEDD (cm) | 4.94 (0.12) | 4.84 (0.08) | 4.82 (0.08) | 4.81 (0.10) |
| LVESD (cm) | 3.41 (0.10) | 3.27 (0.08) | 3.33 (0.09) | 3.29 (0.08) |
| LVEF (%) | 0.66 (0.01) | 0.68 (0.02) | 0.66 (0.01) | 0.67 (0.01) |
| LV mass (g) | 310.25 (14.86) | 274.90 (10.79)* | 274.35 (14.50)* | 278.23 (15.03)* |
| LAD (cm) | 4.12 (0.11) | 3.88 (0.11)* | 3.97 (0.11)∧ | 4.01 (0.15)* |
| E (m/s) | 0.62 (0.03) | 0.67 (0.03) | 0.70 (0.03)* | 0.74 (0.03)* |
| A (m/s) | 0.93 (0.03) | 0.92 (0.03) | 0.93 (0.04) | 0.96 (0.03) |
| E/A | 0.64 (0.03) | 0.71 (0.05) | 0.80 (0.1)* | 0.72 (0.03)* |
| IVRT (ms) | 113.06 (3.84) | 113.20 (3.19) | 115.66 (3.30) | 109.21 (3.42) |
| Sm (cm/s) | 4.54 (0.17) | 4.84 (0.16)∧ | 4.88 (0.17)* | 4.92 (0.16)** |
| Em (cm/s) | 3.79 (0.25) | 4.06 (0.25) | 4.20 (0.23)* | 4.16 (0.25)* |
| E/Em | 18.47 (1.30) | 18.24 (1.02) | 19.64 (1.49) | 20.17 (1.36) |
| Diuretic + Ramipril group | ||||
| Baseline | 12 weeks | 24 weeks | 52 weeks | |
| IVSd (cm) | 1.38 (0.04) | 1.34 (0.04) | 1.37 (0.05) | 1.33 (0.05) |
| LVEDD (cm) | 4.84 (0.08) | 4.87 (0.08) | 4.73 (0.10) | 4.80 (0.10) |
| LVESD (cm) | 3.36 (0.06) | 3.37 (0.07) | 3.22 (0.09) | 3.28 (0.08) |
| LVEF (%) | 0.65 (0.01) | 0.67 (0.01) | 0.68 (0.01) | 0.67 (0.01) |
| LVmass (g) | 292.43 (1020) | 289.99 (13.62) | 285.97 (15.56) | 285.68 (12.33) |
| LAD (cm) | 3.99 (0.12) | 3.90 (0.11) | 3.81 (0.10)∧ | 3.77 (0.12) |
| E (m/s) | 0.66 (0.03) | 0.70 (0.04) | 0.71 (0.04) | 0.69 (0.03) |
| A (m/s) | 0.93 (0.04) | 0.94 (0.03) | 0.91 (0.03) | 0.96 (0.04) |
| E/A | 0.70 (0.04) | 0.71 (0.03) | 0.76 (0.05) | 0.70 (0.03) |
| IVRT (ms) | 119.57 (4.99) | 118.36 (3.12) | 110.82 (3.85)* | 110.45 (3.97) |
| Sm (cm/s) | 4.46 (0.24) | 4.76 (0.22)∧ | 5.02 (0.22)* | 4.94 (0.2)* |
| Em (cm/s) | 3.27 (0.25) | 3.88 (0.27)* | 3.81 (0.26)* | 4.04 (0.32)** |
| E/Em | 24.01 (2.99) | 20.11 (1.73) | 20.98 (2.03) | 19.07 (2.07)* |
Results expressed as mean (SEM).
**p<0.01; *p<0.05 (significant differences between baseline and follow-up at 12, 24 or 52 weeks by paired t tests with Bonferroni adjustment).