| Cumulative anthracycline dose | | Cumulative doses >500 mg/m2 associated with significantly elevated long term risk | | Lipshultz et al 19915; Krischer et al 199712; Lipshultz et al 19956; Lipshultz et al 20057 |
| Length of post-therapy interval | | Incidence of clinically significant cardiotoxicity increases progressively post-therapy | | Lipshultz et al 19915; Lipshultz et al 19956; Lipshultz et al 20057 |
| Rate of anthracycline administration | | Prolonged administration to minimise circulating dose volume may decrease toxicity; results are mixed | | Lipshultz et al 200223 |
| Individual anthracycline dose | | Higher individual anthracycline doses are associated with increased late cardiotoxicity, even when cumulative doses are limited | | Lipshultz et al 19956; Lipshultz et al 20057 |
| Type of anthracycline | | Liposomal encapsulated preparations may reduce cardiotoxicity. Conflicting data exist about anthracycline analogues and cardiotoxicity differences | | Wouters et al 200514; Barry et al 200711; Van Dalen et al 200620 |
| Radiation therapy | | Cumulative radiation dose >30 Gy; prior or concomitant anthracycline treatment | | Giantris et al 19989; Adams et al 200515 |
| Concomitant therapy | | Trastuzumab, cyclophosphamide, bleomycin, vincristine, amsacrine, and mitoxantrone may increase susceptibility/toxicity. Others are implicated as well | | Giantris et al 19989; Barry et al 200711 |
| Pre-existing cardiac risk factors | | Hypertension; ischaemic, myocardial, and valvular heart disease; prior cardiotoxic treatment | | Barry et al 200711 |
| Comorbidities | | Diabetes, obesity, renal dysfunction, pulmonary disease, endocrinopathies, electrolyte and metabolic abnormalities, sepsis, infection, pregnancy | | Barry et al 200711 |
| Age | | Both young and advanced age at treatment are associated with elevated risk | | Lipshultz et al 19915; Lipshultz et al 19956 |
| Sex | | Females are at greater risk than males | | Lipshultz et al 19956 |
| Additional factors | | Trisomy 21; African American ancestry | | Krischer et al 199712 |