Table 1 Patient details
SearchTotal casesDutch score >8 (definite FH)Dutch score 6–8 (probable FH)Sensitivity of finding definite or probable FH cases%Yield of findings Definite or probable FH cases%Number of notes required to search to find one definite or probable case of FHDutch score 3–5 (possible FH)Dutch score <3
IHD1084545 (9/20)8.3 (9/108)12.0 (108/9)4653
Early-onset IHD354545 (9/20)25.7 (9/35)3.9 (35/9)197
FH1510155 (11/20)73.3 (11/15)1.4 (15/11)22
PH561215 (3/20)5.4 (3/56)18.7 (56/3)494
Mixed350210 (2/20)5.7 (2/34)17.0 (34/2)2012
Statin29010890 (18/20)6.2 (18/290)16.1 (290/18)131141
Cholesterol >7.512511685 (17/20)13.6 (17/125)7.4 (125/17)100
Cholesterol >7.0201128100 (20/20)10.0 (20/201)10.1 (201/20)1810
Combined (IHD, lipid diagnosis or statin)343128100 (20/20)5.8 (20/343)17.2 (343/20)157166
Combined and cholesterol >7.0 mmol/l402128100 (20/20)5.0 (20/402)20.1 (402/20)216166
Combined and cholesterol >7.0 after exclusions25212585 (17/20)6.7 (17/252)14.8 (252/17)14689
Chol 7.0 using highest computer cholesterol only1818565 (13/20)7.2 (13/181)13.9 (181/13)1680
Totals40212820216166
  • Twenty found cases using combined and cholesterol >7.0 mmol/l search. If a Poisson distribution is assumed, the 95% CI are from 15.4 to 35.7.

  • FH, familial hypercholesterolaemia; IHD, ischaemic heart disease; PH, pure hypercholesterolaemia.