Table 1 Baseline characteristics between the postinfarction patients and the healthy subjects at entry into the study
Healthy controls (n = 19)Postinfarction patients (n = 39)p Value (healthy controls vs all postinfarction patients)p Value (non-training group vs training group)
Non-training group (n = 19)Training group (n = 20)
Age (years)50 (36 to 62)52 (39 to 65)52 (38 to 65)0.250.99
Body surface area (m2)1.76 (0.13)1.80 (0.13)1.81 (0.12)0.160.81
Peak oxygen uptake (ml/kg/min)26.3 (4.4)22.7 (3.1)22.2 (3.9)0.0020.66
LV ejection fraction (%)74 (6)62 (13)58 (12)<0.0010.33
Cardiac index (l/min/m2)3.1 (0.4)3.0 (0.6)3.1 (0.5)0.990.58
LV mass index (g/m2)58 (17)75 (14)79 (16)0.0010.42
Infarct size (g)22 (11)29 (15)0.10
Blood flow in remote myocardium
    At rest (ml/min/g)1.15 (0.24)1.07 (0.18)1.03 (0.19)0.130.50
    At stress (ml/min/g)2.77 (0.78)2.59 (0.64)2.36 (0.87)0.170.35
Blood flow in infarcted myocardium
    At rest (ml/min/g)1.15 (0.24)*1.07 (0.37)0.92 (0.34)0.140.20
    At stress (ml/min/g)2.77 (0.78)*1.70 (0.52)1.61 (0.65)<0.0010.64
Stromal-derived factor-1 (pg/ml)1869 (309)2104 (309)2118 (344)0.0090.89
Vascular endothelial growth factor (pg/ml)2.77 (0.59)3.46 (0.61)3.54 (0.62)<0.0010.69
Stem cell factor (pg/ml)524 (193)568 (85)625 (163)0.150.18
Left anterior descending artery as infarct-related artery12 (63%)12 (60%)0.87
Postinfarction period (months)7.9 (3.5)8.6 (3.3)0.53
Hypertension08 (42%)9 (45%)<0.0010.88
Diabetes mellitus03 (16%)3 (15%)0.120.83
Hyperlipidaemia08 (42%)7 (35%)<0.0010.63
Remote smokers07 (37%)6 (30%)0.0030.62
Active smokers0000.500.50
Angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers use011 (58%)13 (65%)<0.0010.63
Beta-blocker use015 (78%)15 (75%)<0.0010.86
Statin use08 (42%)7 (35%)<0.0010.63
  • *The reference values of blood flow in infarcted myocardium are the same as those in remote myocardium in healthy controls. All values are expressed as mean (SD) or the number (%) of patients except age expressed as median and range. The value of vascular endothelial growth factor has been logarithmically transformed. Hypertension is defined as a repeatedly elevated blood pressure ⩾140/90 mm Hg or current use of antihypertensive medication. Hyperlipidaemia is defined as fasting total cholesterol ⩾5.27 mmol/l, low-density lipoprotein (LDL) cholesterol ⩾3.42 mmol/l, triglyceride ⩾2.27 mmol/l or current use of lipid-lowering drugs.

  • LV, left ventricular.