Table 2 Exercise capacity, cardiac MRI measures and angiogenic cytokines at baseline and 3-month follow-up
BaselineFollow-upChangeTraining effectp Value
Non-trainingTrainingNon-trainingTrainingNon-trainingTraining
Peak oxygen uptake (ml/kg/min)22.7 (3.1)22.2 (3.9)22.4 (3.0)25.0 (5.0)−0.3 (3.0)3.0 (4.4)3.0 (0.8 to 5.3)0.01
LV ejection fraction, %62 (13)58 (12)62 (12)60 (12)0 (4)1 (6)0.7 (−2.7 to 4.1)0.69
Cardiac index, l/min/m23.0 (0.6)3.1 (0.5)3.0 (0.6)3.1 (0.5)0 (0.3)0 (0.5)0 (−0.3 to 0.3)0.97
LV mass index, g/m275 (14)79 (16)77 (15)77 (15)1 (11)−3 (15)−3 (−11 to 6)0.53
Infarct size, g22 (11)29 (15)22 (11)27 (13)0 (4)−2 (5)−2 (−5 to 1)0.19
Perfusion in remote myocardium
    Rest (ml/min/g)1.07 (0.18)1.03 (0.19)1.07 (0.14)1.21 (0.26)0.00 (0.22)0.18 (0.31)0.05 (−0.10 to 0.20)0.49
    Stress (ml/min/g)2.59 (0.64)2.36 (0.87)2.32 (0.48)2.98 (0.90)−0.27 (0.56)0.62 (0.83)0.79 (0.38 to 1.20)<0.001
Perfusion in infarcted myocardium
    Rest (ml/min/g)1.07 (0.37)0.92 (0.34)0.89 (0.22)0.94 (0.27)−0.18 (0.46)0.02 (0.41)0.05 (−0.12 to 0.21)0.58
    Stress (ml/min/g)1.70 (0.52)1.61 (0.65)1.70 (0.52)2.05 (0.83)0.00 (0.46)0.44 (0.71)0.45 (0.07 to 0.83)0.02
Stromal-derived factor-1 (pg/ml)2104 (309)2118 (344)2070 (311)1876 (343)−68 (175)−196 (209)−131 (−246 to −16)0.02
Vascular endothelial growth factor (pg/ml)3.46 (0.61)3.54 (0.62)3.51 (0.59)3.22 (0.63)−0.05 (0.38)−0.35 (0.35)−0.31 (−0.52 to −0.09)0.01
Stem cell factor (pg/ml)568 (85)625 (163)585 (60)645 (164)17 (47)20 (120)20 (−37 to 76)0.49
  • Training effects expressed as differences in least-squares means (model of analyses of covariance) with 95% CI. The value of vascular endothelial growth factor has been logarithmically transformed.

  • LV, left ventricular.