Univariate and multivariate indicators of definite events (death, myocardial infarction) and major events (death, myocardial infarction, late revascularisation)
| Definite events | Major events | |||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Age (years) | 1.02 (1.00 to 1.05) | 0.06 | 1.03 (1.01 to 1.05) | 0.006 | ||||
| Gender (female) | 1.52 (0.87 to 2.67) | 0.15 | 1.08 (0.69 to 1.70) | 0.73 | ||||
| Prior myocardial infarction | 1.63 (0.88 to 3.04) | 0.12 | 2.07 (1.29 to 3.33) | 0.003 | ||||
| Prior CABG | 2.09 (0.75 to 5.82) | 0.16 | 1.99 (0.86 to 4.57) | 0.11 | ||||
| Prior PCI | 0.43 (0.16 to 1.21) | 0.11 | 0.57 (0.27 to 1.18) | 0.13 | ||||
| Left bundle branch block | 0.94 (0.29 to 3.01) | 0.91 | 0.97 (0.39 to 2.41) | 0.96 | ||||
| Family history of CAD | 1.28 (0.55 to 3.03) | 0.58 | 1.18 (0.59 to 2.37) | 0.64 | ||||
| Diabetes mellitus | 2.01 (1.09 to 4.05) | 0.03 | 1.97 (1.01 to 3.86) | 0.05 | 2.63 (1.61 to 2.30) | <0.0001 | 2.22 (1.30 to 3.79) | 0.003 |
| Arterial hypertension | 2.65 (1.38 to 5.10) | 0.004 | 2.13 (1.29 to 3.51) | 0.003 | ||||
| Hypercholesterolaemia | 1.32 (0.74 to 2.36) | 0.35 | 1.64 (1.01 to 2.67) | 0.04 | ||||
| Smoking habit | 0.73 (0.39 to 1.35) | 0.31 | 1.06 (0.66 to 1.68) | 0.82 | ||||
| Anti-ischaemic therapy | ||||||||
| at the time of test | 3.23 (1.61 to 6.47) | 0.001 | 3.31 (1.80 to 5.44) | <0.0001 | 2.14 (1.13 to 4.03) | 0.02 | ||
| Resting WMSI | 1.46 (0.51 to 4.21) | 0.48 | 2.29 (1.10 to 4.76) | 0.03 | ||||
| Resting EF | 0.98 (0.95 to 1.02) | 0.37 | 0.97 (0.94 to 0.99) | 0.02 | ||||
| Resting WMA | 1.62 (0.90 to 2.89) | 0.11 | 2.31 (1.47 to 3.63) | <0.0001 | 3.43 (1.60 to 7.34) | 0.001 | ||
| CFR ⩽2.0 on LAD | 13.76 (7.15 to 26.48) | <0.0001 | 11.97 (5.49 to 26.11) | <0.0001 | 7.17 (4.48 to 11.46) | <0.0001 | 5.30 (2.91 to 9.63) | <0.0001 |
| CFR ⩽2.0 on RCA | 4.68 (2.67 to 8.23) | <0.0001 | 4.68 (2. 98 to 7.37) | <0.0001 | ||||
CI, confidence interval; HR, hazard ratio.
CABG, coronary artery bypass grafting; CAD, coronary artery disease; CFR, coronary flow reserve; EF, ejection fraction; LAD, left anterior descending artery; PCI, percutaneous coronary intervention; RCA, right coronary artery; WMA, wall motion abnormality; WMSI, wall motion score index.