Intravascular ultrasound (IVUS) and virtual histology (VH) findings according to segmental response to acetylcholine
| Normal response | Endothelial dysfunction | Difference | p Value* | |
| Analysis of grey scale IVUS | ||||
| Vessel area (mm2) | 12.6 (4) | 11.8 (3.4) | 0.8 (2.8) | 0.11 |
| Lumen area (mm2) | 8.8 (3.3) | 7.5 (2.4) | 1.3 (2.4) | 0.006 |
| Plaque area (mm2) | 3.9 (1.1) | 4.3 (1.7) | −0.4 (1.3) | 0.09 |
| Plaque burden (%) | 31.7 (6.9) | 37.1 (9.4) | 5.4 (9.0) | 0.003 |
| Area of the each plaque constituent | p Value** | |||
| Fibrous area (mm2) | 0.18 | |||
| Median (Q1–Q3) | 0.44 (0.13–0.80) | 0.30 (0.10–1.20) | 0.12 (−0.23–0.77) | |
| Min, max | 0.0, 2.37 | 0.0, 4.43 | −1.50, 2.07 | |
| Fibrofatty area (mm2) | 0.23 | |||
| Median (Q1–Q3) | 0.04 (0–0.17) | 0.08 (0.0–0.13) | 0.0 (−0.03–0.10) | |
| Min, max | 0.0, 0.57 | 0.0, 0.67 | −0.20, 0.30 | |
| Dense calcium area (mm2) | <0.001 | |||
| Median (Q1–Q3) | 0.0 (0.0–0.0) | 0.03 (0.0–0.13) | 0.0 (0.0–0.13) | |
| Min, Max | 0.0, 0.10 | 0.0, 0.53 | −0.05, 0.53 | |
| Necrotic core area (mm2) | <0.001 | |||
| Median (Q1–Q3) | 0.0 (0.0–0.07) | 0.13 (0.03–0.33) | 0.10 (0.01–0.29) | |
| Min, max | 0.0, 0.30 | 0.0, 1.33 | −0.05, 1.10 |
*Paired t test. Mean (SD).
**Signed rank test.