Diagnostic performance of CT angiography (CTA) and exercise electrocardiography (XECG) for detection of (invasive) angiographic significant coronary artery disease, per patient (n = 98)
| Analysis | Excl | TP | TN | FP | FN | Sensitivity (%)Mean (95% CI) | Specificity (%)Mean (95% CI) | Positive PV (%)Mean (95% CI) | Negative PV (%)Mean (95% CI) |
| Per patient analysis, ⩾50% QCA stenosis | |||||||||
| CTA (⩾50% stenosis) | 2 | 53 | 15 | 26 | 2 | 96 (86 to 99) | 37 (23 to 53) | 67 (55 to 77) | 88 (62 to 98) |
| XECG | 39 | 24 | 19 | 6 | 10 | 71 (52 to 84) | 76 (54 to 90) | 80 (61 to 92) | 66 (46 to 81) |
| CTA + XECG | 40 | 22 | 22 | 3 | 11 | 67 (51 to 83) | 88 (75 to 100) | 88 (75 to 100) | 67 (48 to 85) |
| Per patient analysis, ⩾50% QCA stenosis, intention to diagnose | |||||||||
| CTA (⩾50% stenosis) | – | 55 | 15 | 26 | 2 | 96 (87 to 99) | 37 (23 to 53) | 68 (56 to 78) | 88 (62 to 98) |
| XECG | – | 47 | 19 | 22 | 10 | 82 (70 to 91) | 46 (31 to 62) | 68 (56 to 79) | 66 (46 to 81) |
| Per patient analysis, ⩾70% QCA stenosis | |||||||||
| CTA (⩾50% stenosis) | 2 | 27 | 16 | 52 | 1 | 96 (80 to 100) | 24 (14 to 36) | 34 (24 to 46) | 94 (69 to 100) |
| XECG | 39 | 16 | 25 | 14 | 4 | 80 (56 to 93) | 64 (47 to 78) | 53 (35 to 71) | 86 (67 to 95) |
| CTA + XECG | 40 | 15 | 29 | 10 | 4 | 79 (61 to 97) | 74 (61 to 88) | 60 (41 to 79) | 88 (75 to 100) |
| Per patient analysis, ⩾70% QCA stenosis, intention to diagnose | |||||||||
| CTA (⩾50% stenosis) | – | 28 | 17 | 52 | 1 | 97 (80 to 100) | 25 (15 to 37) | 35 (25 to 47) | 94 (71 to 100) |
| XECG | – | 25 | 25 | 44 | 4 | 86 (67 to 95) | 36 (25 to 49) | 36 (25 to 49) | 86 (67 to 95) |
| Per vessel analysis, CT angiography (⩾50% stenosis) | |||||||||
| >50% QCA stenosis | 8 | 83 | 218 | 68 | 15 | 85 (78 to 92) | 76 (71 to 81) | 55 (47 to 63) | 94 (90 to 98) |
| Diagnostic XECG | 4 | 52 | 133 | 41 | 6 | 90 (82 to 98) | 76 (70 to 83) | 56 (46 to 66) | 96 (92 to 100) |
| Non-diagnostic XECG | 4 | 31 | 85 | 27 | 9 | 78 (65 to 90) | 76 (68 to 84) | 53 (41 to 66) | 90 (83 to 98) |
| >70% QCA stenosis | 8 | 27 | 229 | 124 | 4 | 87 (75 to 99) | 65 (60 to 70) | 18 (12 to 24) | 98 (96 to 100) |
Diagnostic performance of (CTA), exercise ECG (XECG), or combined (with both tests required positive), by per patient or per vessel analysis, using either a >50% or >70% quantitative catheter angiography (QCA) threshold as reference. Unavailable data were excluded, or assumed positive in the intention-to-diagnose analysis. Subanalysis in patients with diagnostic or non-diagnostic XECG results (including XECGs not performed).
FN, false negative; FP, false positive; PV, predictive value; TN, true negative; TP, true positive.