Table 3

Diagnostic accuracy of quantitative myocardial contrast echocardiographic perfusion parameters at the territorial level

ReserveAUCSensitivity*Specificity†LR+‡ (95% CI)LR−§ (95% CI)
Sensitivity % (95% CI)RatioSpecificity % (95% CI)Ratio
β (cut-off, 1.60)
    LAD0.78183 (74 to 89)67/8164 (62 to 65)333/5242.27 (1.95 to 2.52)0.27 (0.17 to 0.42)
    Cx0.82280 (60 to 92)16/2072 (70 to 74)126/1742.86 (2.0 to 3.45)0.28 (0.11 to 0.57)
    RCA0.78679 (63 to 90)23/2967 (64 to 69)99/1472.44 (1.77 to 2.94)0.31 (0.15 to 0.57)
MBF (cut-off, 1.90)
    LAD0.77372 (62 to 80)58/8171 (70 to 73)374/5242.50 (2.05 to 2.92)0.39 (0.28 to 0.55)
    Cx0.88585 (65 to 95)17/2074 (71 to 75)128/1743.22 (2.28 to 3.74)0.20 (0.07 to 0.45)
    RCA0.73969 (53 to 82)20/2977 (74 to 79)113/1472.98 (2.0 to 3.98)0.40 (0.23 to 0.64)
  • *Number of true positives/total number of abnormal segments.

  • †Number of true negatives/total number of normal segments.

  • ‡LR+  =  sensitivity/(1 − specificity).

  • §LR−  =  (1 − sensitivity)/specificity.

  • AUC, area under the receiver operating characteristic curve; β, rate of signal intensity increase, reflecting myocardial blood flow velocity; Cx, left circumflex coronary artery; LAD, left anterior descending coronary artery; LR−, negative likelihood ratio; LR+, positive likelihood ratio; MBF, myocardial blood flow; RCA, right coronary artery.