Studies of CIMT progression among patients with HIV
| Author | No | Mean baseline CIMT (SD) | Mean final CIMT (SD) | CIMT Δmm/year | Follow-up(months) | p Value |
| Hsue15 | Compared rate of CIMT progression for HIV+ with HIV− and by PI exposure | |||||
| HIV+ | 121 | 0.93 (0.32) | 1.00 (0.41) | 0.074 | 12 | <0.001 |
| HIV− | 27 | 0.71 (0.14) | 0.70 (0.15) | −0.006 | 12 | 0.53 |
| PI | N/A | N/A | N/A | N/A | N/A | N/A |
| Conclusion | “Carotid IMT is higher in patients with HIV than in age-matched control subjects and progresses much more rapidly…. carotid IMT is associated with classic coronary risk factors and with nadir CD4 count <200….protease inhibitor treatment itself, triglycerides and HDL cholesterol were not independent predictors of increased carotid IMT in our study” | |||||
| Currier52 | Compared rate of CIMT progression for HIV+ with HIV− and by PI exposure | |||||
| HIV+/PI− | 45 | 0.712 | N/A | 0.0058 | 36 | N/A |
| HIV− | 45 | 0.698 | N/A | 0.0085 | 36 | N/A |
| HIV+/PI+ | 45 | 0.690 | N/A | 0.0096 | 36 | N/A |
| Conclusion | “HIV infection and PI use did not contribute substantially to the rate of carotid IMT progression in our matched study…predictors of progression in carotid IMT [were]…LDL, homocysteine, nadir CD4 cell count and ritonavir use.” | |||||
| Mercie26 | Compared rate of IMT progression by PI exposure among HIV+ | |||||
| HIV+ | 346 | 0.57 (0.1) | 0.59 (0.1) | 0.02 | 12 | <0.001 |
| HIV− | 0 | N/A | N/A | N/A | N/A | N/A |
| PI | 180 | N/A | N/A | N/A | N/A | N/A |
| Conclusion | “Conventional cardiovascular risk factors induce mild atherosclerosis progression in HIV-infected patients and higher CD4 cell count can be related to atherosclerosis disease progression…The effects of HAART and lipodystrophy were no longer statistically significant when adjusted for other cardiovascular risk factors” | |||||
CIMT, carotid intima-media thickness; HAART, highly active antiretroviral therapy; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PI, protease inhibitor.