Area under the ROC curve values of clinical endpoints
| Variable | AUC (95% CI) | p Value |
| Endpoint = recurrent ACS* | ||
| BNP | 0.603 (0.525 to 0.680) | 0.023 |
| GRACE | 0.600 (0.518 to 0.681) | 0.027 |
| TRI | 0.512 (0.424 to 0.601) | 0.424 |
| Endpoint = CHF* | ||
| BNP | 0.689 (0.565 to 0.812) | 0.003 |
| GRACE | 0.663 (0.554 to 0.773) | 0.010 |
| TRI | 0.714 (0.609 to 0.819) | 0.001 |
| Endpoint = recurrent ACS/mortality | ||
| BNP | 0.704 (0.531 to 0.675) | <0.001 |
| GRACE | 0.643 (0.572 to 0.715) | <0.001 |
| TRI | 0.603 (0.531 to 0.675) | 0.006 |
| BNP/GRACE | 0.708 (0.646 to 0.770) | <0.001 |
| Endpoint = CHF/mortality | ||
| BNP | 0.751 (0.679 to 0.824) | <0.001 |
| GRACE | 0.738 (0.665 to 0.811) | <0.001 |
| TRI | 0.748 (0.680 to 0.816) | <0.001 |
| BNP/GRACE | 0.774 (0.705 to 0.843) | <0.001 |
| Endpoint = mortality | ||
| BNP | 0.806 (0.733 to 0.878) | <0.001 |
| GRACE | 0.789 (0.704 to 0.873) | <0.001 |
| TRI | 0.756 (0.677 to 0.835) | <0.001 |
| BNP/GRACE | 0.832 (0.765 to 0.898) | <0.001 |
| Endpoints = all CV events (ACS/CHF or mortality) | ||
| BNP | 0.701 (0.641 to 0.761) | <0.001 |
| GRACE | 0.649 (0.586 to 0.713) | <0.001 |
| TRI | 0.635 (0.570 to 0.700) | <0.001 |
| BNP/GRACE | 0.707 (0.649 to 0.766) | <0.001 |
*A combined BNP/GRACE score was not constructed because BNP was the only independent predictor of the particular endpoint on multivariate analysis.
ACS, acute coronary syndrome; BNP, B-type natriuretic peptide; CHF, congestive heart failure; GRACE, Global Registry of Acute Coronary Events; TRI, thrombolysis in myocardial infarction risk index.