Table 4 Re-infarction rates for pre-hospital and in-hospital treatment in relation to interval from onset of symptoms

	Reteplase					Tenecteplase
	In-hospital (a)		Pre-hospital (b)		*b – a, p value	In-hospital (a)		Pre-hospital (b)		*b – a, p value
	%	No	%	No	*b – a, p value	%	No	%	No	*b – a, p value
0–2 hours	6.8	86/1258	7.0	26/371	0.2, NS	7.4	208/2801	10.9	140/1287	3.5, p<0.001
2–4 hours	6.0	78/1305	6.3	9/144	0.3, NS	5.8	139/2399	6.8	34/499	1.0, NS
>4 hours	6.2	56/903	5.4	4/74	−0.8, NS	5.0	84/1682	8.9	21/237	3.9, p = 0.014
Total	6.3	220/3466	6.6	39/589	0.3, NS	6.3	431/6882	9.6	195/2023	3.6, p<0.001

*b − a is the difference between pre-hospital and in-hospital treatment re-infarction rates.
NS, not significant (p>0.05).