Table 4 Hazard ratios and 95% confidence intervals of mortality according to moderate-to-vigorous physical activity time
Physical activity (min/week)Person-yearsDeaths(n/total n)Model 1†Model 2‡Model 3§Model 4¶
HR (95% CI)Trend p valueHR (95% CI)Trend p valueHR (95% CI)Trend p valueHR (95% CI)Trend p value
Death from any cause*
Unmedicated<0.001<0.001<0.001n/a
    None (referent)24 378452/3685
    <15035 756256/51960.62 (0.53 to 0.73)0.67 (0.57 to 0.79)0.70 (0.60 to 0.82)
    ⩾15054 465215/80910.46 (0.39 to 0.55)0.54 (0.46 to 0.65)0.58 (0.48 to 0.69)
Medicated<0.001<0.001<0.001<0.001
    None (referent)6964276/1175
    <1506067108/9610.56 (0.45 to 0.70)0.59 (0.47 to 0.74)0.61 (0.49 to 0.77)0.62 (0.50 to 0.79)
    ⩾150580465/9320.45 (0.34 to 0.60)0.50 (0.38 to 0.67)0.51 (0.39 to 0.69)0.54 (0.40 to 0.72)
Death from cardiovascular causes*
Unmedicated<0.0010.0090.036n/a
    None (referent)24 378120/3685
    <15035 75669/51960.68 (0.50 to 0.91)0.72 (0.53 to 0.98)0.76 (0.56 to 1.04)
    ⩾1505446557/80910.52 (0.37 to 0.73)0.60 (0.43 to 0.85)0.65 (0.46 to 0.91)
Medicated<0.0010.0010.0050.008
    None (referent)6964101/1175
    <150606744/9610.62 (0.43 to 0.88)0.66 (0.46 to 0.95)0.69 (0.48 to 1.00)0.70 (0.48 to 1.01)
    ⩾150580419/9320.37 (0.23 to 0.62)0.42 (0.25 to 0.69)0.45 (0.26 to 0.75)0.46 (0.27 to 0.78)
  • Respondents had no self-reported diagnosis of coronary heart disease (angina or myocardial infarction) or stroke.

  • *Excluding deaths that occurred during the first 12 months of follow-up; †model 1, adjusted for sex and age; ‡model 2, as model 1 plus ethnicity, social class, marital status, alcohol drinking, occupational physical activity, smoking, parental cause of death and general household questionnaire score; §model 3, as model 2 plus non-cardiovascular disease long-standing illness, doctor-diagnosed diabetes, body mass index class, and hypertension (doctor-diagnosed or based on survey reading); ¶model 4, as model 3 plus cardiovascular medication type (lipid-lowering, diuretics, β blockers, ACE inhibitors, calcium blockers, or other) and number of prescribed cardiovascular drugs.