Table 1

Baseline characteristics of new users of statins and non-users of statins aged 30–84 years in the QResearch derivation and THIN validation cohorts. Figures in the tables are counts (%) unless otherwise specified

CharacteristicsQResearch derivation cohortTHIN validation cohort
New users of statinsNon-users of statinsNew users of statinsNon-users of statins
Total225922 (100.00)1778770 (100.00)282056 (100.00)1923840 (100.00)
Female104774 (46.38)909423 (51.13)129085 (45.77)988038 (51.36)
Male121148 (53.62)869347 (48.87)152971 (54.23)935802 (48.64)
Age, mean (SD)57.2 (11.7)44.4 (13.7)59.2 (11.8)46 (13.9)
Ethnicity
Ethnicity recorded121355 (53.72)569466 (32.01)54627 (19.37)303572 (15.78)
White/not recorded215077 (95.20)1699991 (95.57)275014 (97.50)1873857 (97.40)
Indian2861 (1.27)13398 (0.75)2153 (0.76)10793 (0.56)
Pakistani1658 (0.73)7562 (0.43)776 (0.28)3430 (0.18)
Bangladeshi679 (0.30)3226 (0.18)262 (0.09)1224 (0.06)
Other Asian759 (0.34)7321 (0.41)809 (0.29)5930 (0.31)
Caribbean1788 (0.79)9853 (0.55)982 (0.35)4849 (0.25)
Black African834 (0.37)15358 (0.86)609 (0.22)8967 (0.47)
Chinese316 (0.14)4015 (0.23)151 (0.05)2206 (0.11)
Other ethnic group1950 (0.86)18046 (1.01)1300 (0.46)12584 (0.65)
BMI and smoking
BMI recorded207644 (91.91)1341863 (75.44)255544 (90.60)1444453 (75.08)
Smoking status recorded224982 (99.58)1615527 (90.82)279998 (99.27)1758891 (91.43)
BMI and smoking status recorded207494 (91.84)1330320 (74.79)255310 (90.52)1433122 (74.49)
Body mass index, mean (SD)28.3 (4.9)26 (4.6)28.3 (4.9)26.1 (4.6)
Non-smoker109406 (48.43)912149 (51.28)115122 (40.82)795944 (41.37)
Ex-smoker74277 (32.88)285271 (16.04)99446 (35.26)253294 (13.17)
Current smoker (amount not recorded)2286 (1.01)55859 (3.14)10376 (3.68)239225 (12.43)
Current smoker (light)14447 (6.39)116035 (6.52)15406 (5.46)120385 (6.26)
Current smoker (moderate)13880 (6.14)142469 (8.01)20494 (7.27)186825 (9.71)
Current smoker (heavy)10686 (4.73)103744 (5.83)19154 (6.79)163218 (8.48)
Townsend score, mean (SD)−0.5 (3.3)−0.3 (3.4)−0.5 (3.1)−0.7 (3.1)
Comorbidity
Atrial fibrillation11656 (5.16)13730 (0.77)13951 (4.95)15149 (0.79)
Congestive cardiac failure7457 (3.30)9026 (0.51)8802 (3.12)9707 (0.50)
Cardiovascular disease56943 (25.20)31038 (1.74)77244 (27.39)33838 (1.76)
Treated hypertension97782 (43.28)106582 (5.99)107572 (38.14)99559 (5.18)
Chronic kidney disease 3b+18768 (8.31)17114 (0.96)19156 (6.79)13032 (0.68)
Type 1 diabetes2843 (1.26)2633 (0.15)3829 (1.36)2945 (0.15)
Type 2 diabetes47703 (21.11)18243 (1.03)58860 (20.87)18348 (0.95)
Rheumatoid arthritis3652 (1.62)11762 (0.66)5155 (1.83)14660 (0.76)
Corticosteroids13868 (6.14)44517 (2.50)16816 (5.96)50505 (2.63)
Hypothyroidism12378 (5.48)30357 (1.71)17675 (6.27)38441 (2.00)
Clinical values
Systolic blood pressure, mean (SD)141.1 (19.1)129.9 (19.1)140.7 (19.1)130.4 (19.2)
LFT recorded at baseline/before statins131354 (58.14)162207 (9.12)135793 (48.14)90162 (4.69)
LFT recorded at follow-up193586 (85.69)594750 (33.44)224024 (79.43)578686 (30.08)
Creatine kinase recorded at baseline/before statins15724 (6.96)8642 (0.49)13651 (4.84)4807 (0.25)
Creatine kinase recorded at follow-up62706 (27.76)43333 (2.44)57400 (20.35)42062 (2.19)
  • BMI, body mass index; LFT, liver function test.