The associations of family histories of type-2 diabetes (T2DM) and cardiovascular disease (CVD), whole-body insulin sensitivity (M-value) and plasma low-density-lipoprotein (LDL) cholesterol with intima media thickness (IMT) of common and internal carotid artery in all participants as well as LDL+ and insulin-resistance (IR) subcohort, using multiple linear regression analyses
| All participants | LDL+ subcohort | IR subcohort | ||||
| β±SE (p values) | β±SE (p values) | β±SE (p values) | ||||
| Common carotid artery intima media thickness | ||||||
| Family history of T2DM | ||||||
| Family history of CVD | 0.029±0.012 | (p=0.016) | ||||
| M-value | −0.002±0.001 | (p=0.033) | −0.004±0.002 | (p=0.038) | ||
| Plasma LDL-C | 0.028±0.003 | (p<0.001) | 0.041±0.011 | (p<0.001) | 0.031±0.007 | (p<0.001) |
| r | 0.282 | 0.309 | 0.287 | |||
| Internal carotid artery intima media thickness | ||||||
| Family history of T2DM | ||||||
| Family history of CVD | 0.067±0.022 | (p=0.003) | ||||
| M-value | ||||||
| Plasma LDL-C | 0.038±0.006 | (p<0.001) | 0.054±0.013 | (p<0.001) | ||
| r | 0.236 | 0.217 | 0.279 | |||