Correlation between markers of tubular damage and renal function parameters
| Variable | Univariate correlation coefficient (95% CI) | ||
| NGAL | NAG | KIM-1 | |
| Tubular markers | |||
| NGAL | NA | 0.15 (−0.06 to 0.35) | 0.16 (−0.05 to 0.35) |
| NAG | 0.15 (−0.06 to 0.35) | NA | 0.13 (−0.08 to 0.33) |
| KIM-1 | 0.16 (−0.05 to 0.35) | 0.13 (−0.08 to 0.33) | NA |
| Renal function measurements | |||
| GFR | −0.07 (−0.27 to 0.14) | −0.34 (−0.51 to −0.14)** | −0.01 (−0.22 to 0.20) |
| ERPF | −0.06 (−0.26 to 0.15) | −0.29 (−0.47 to −0.09)** | −0.11 (−0.31 to 0.10) |
| Filtration fraction | 0.04 (−0.17 to 0.25) | −0.16 (−0.36 to 0.05) | 0.17 (−0.04 to 0.36) |
| UAE | 0.10 (−0.11 to 0.30) | 0.16 (−0.05 to 0.35) | 0.21 (−0.01 to 0.40) |
| NT-proBNP | −0.03 (−0.24 to 0.18) | 0.21 (0.00 to 0.40)* | 0.23 (0.02 to 0.42)* |
N=90, all patients with chronic heart failure.
↵* p<0.05;
↵** p<0.01.
ERPF, effective renal plasma flow; GFR, glomerular filtration rate; KIM-1, kidney injury molecule 1; NAG, N-acetyl-β-D-glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin; NT-proBNP, N-terminal pro-brain natriuretic peptide; UAE, urinary albumin excretion.