Table 3

Univariate and adjusted Cox proportional hazard analysis for urinary NAG, NGAL and KIM-1 as predictors for the combined end point

Predictor variableUrinary NGAL (per 100 μg/gCr) (HR (95% CI))p ValueUrinary NAG (per 5 U/gCr) (HR (95% CI))p ValueUrinary KIM-1 (per 100 ng/gCr) (HR (95% CI))p Value
Unadjusted1.02 (0.87 to 0.20)NS1.43 (1.10 to 1.84)0.0071.13 (1.00 to 1.28)0.047
Adjusted for GFR1.01 (0.88 to 1.16)NS1.42 (1.02 to 1.94)0.0391.15 (1.02 to 1.30)0.025
Adjusted for serum creatinine1.03 (0.89 to 1.19)NS1.49 (1.11 to 2.00)0.0081.18 (1.04 to 1.33)0.009
Adjusted for Age, gender, LVEF, SBP, DBP, Hb, GFR, NT-proBNP and UAE1.01 (0.85 to 1.19)NS1.46 (0.98 to 2.17)0.0661.16 (1.00 to 1.35)0.046
  • N=90, all patients with chronic heart failure.

  • CI, confidence interval; DBP, diastolic blood pressure; gCr, gram urinary creatinine; GFR, glomerular filtration rate; Hb, haemoglobin levels; HR, hazards ratio; KIM-1, kidney injury molecule 1; LVEF, left ventricular ejection fraction; NAG, N-acetyl-β-D-glucosaminidase; NGAL, neutrophil gelatinase-associated lipocalin; NT-proBNP, N terminal pro-brain natriuretic peptide; SBP, systolic blood pressure; UAE, urinary albumin excretion.