Clinical, echocardiographic, and catheterisation data of 333 patients with aortic valve stenosis (AVA<1.0 cm2) and the subgroups with inconsistent grading (catheter-derived AVA<1.0 cm2 and ΔPm<40 mm Hg) and consistent severe stenosis (AVA<1.0 cm2 and ΔPm>40 mm Hg)
Aortic valve stenosis | |||||
All patients | Inconsistent | Consistent | p Value | ||
(n=333) | AVA<1.0 cm2 ΔPm≤40 mm Hg (n=85) | AVA<1.0 cm2 ΔPm>40 mm Hg (n=153) | |||
Clinical data | |||||
Age | years | 67.6±10.5 | 71±11 | 67±11 | 0.006 |
Female | % | 45 | 59 | 49 | 0.18 |
Height | cm | 167±9 | 163±8 | 166±8 | 0.01 |
Weight | kg | 76±13 | 73±12 | 74±12 | 0.52 |
BSA | m2 | 1.87±0.2 | 1.82±0.2 | 1.85±0.2 | 0.23 |
Systolic BP | mm Hg | 140±23 | 144±25 | 138±22 | 0.04 |
Diastolic BP | mm Hg | 70±ll | 69±12 | 70±10 | 0.41 |
CAD | % | 45 | 53 | 39 | 0.06 |
Hypertension | % | 67 | 80 | 57 | 0.001 |
Hypercholesterolaemia | % | 72 | 68 | 73 | 0.46 |
Diabetes mellitus | % | 18 | 22 | 16 | 0.30 |
Echocardiography | |||||
LV diameter | |||||
End-diastolic | mm | 47.2±5.8 | 45.8±5.4 | 47.0±5.9 | 0.13 |
End-systolic | mm | 28.9±5.3 | 28.2±4.9 | 28.8±5.1 | 0.39 |
Shortening fraction | % | 39.1±6.3 | 38.9±6.1 | 39.1±6.1 | 0.77 |
LVOT | |||||
Diameter | mm | 19.9±1.6 | 19.5±1.5 | 19.8±1.5 | 0.23 |
Vmax | m/s | 1.0±0.16 | 1.0±0.2 | 1.0±0.2 | 0.19 |
Vmean | m/s | 0.68±0.11 | 0.68±0.1i | 0.68±0.11 | 0.72 |
Aortic valve | |||||
Vmax | m/s | 4.43±0.66 | 4.16±0.50 | 4.8±0.55 | 0.001 |
Vmean | m/s | 3.15±0.55 | 2.93±0.39 | 3.48=049 | 0.001 |
ΔPm | mm Hg | 45.8±15.3 | 39.4±10.6 | 54.9±14.3 | 0.001 |
Area | cm2 | 0.73±0.17 | 0.76±0.12 | 0.66±0.16 | 0.001 |
Indexed area | cm2/m2 | 0.39±0.09 | 0.42±0.07 | 0.36±0.09 | 0.001 |
Stroke volume | m/s | 70±14 | 67±12 | 69±14 | 0.35 |
Stroke volume index | ml/m2 | 37.5±7.1 | 37.1±6.6 | 37.4±7.4 | 0.79 |
Cardiac catheterisation | |||||
Heart rate | /min | 71.0±13 | 70.1±12.2 | 72.3±14.0 | 0.44 |
Ejection period | s | 0.36±0.05 | 0.36±0.05 | 0.36±0.05 | 0.78 |
Cardiac output | 1/mm | 5.1±1.1 | 4.4±0.9 | 5.0±1.0 | 0.001 |
Cardiac index | 1/min/m2 | 2.7±0.5 | 2.5±0.5 | 2.7±0.5 | 0.001 |
Stroke volume | ml | 72.9±17.7 | 63.2±13.6 | 70.1±14.8 | 0.001 |
Stroke volume index | ml/m2 | 39.4±8.3 | 35.3±6.9 | 38.7±7.2 | 0.001 |
Aortic valve | |||||
ΔPm | mm Hg | 42.6±17.1 | 32.4±5.9 | 56.7±12.9 | 0.001 |
area | cm | 0.88±0.3 | 0.80±0.1 | 0.69±0.1 | 0.001 |
indexed area | cm2/m2 | 0.47±0.15 | 0.44±0.07 | 0.37±0.07 | 0.001 |
p values are for comparison of inconsistent versus consistent grading.
AVA, aortic valve area; BSA, body surface area; BP, blood pressure; CAD, coronary artery disease; LV, left ventricular; LVOT, left ventricular outflow tract; ΔPm, mean pressure gradient.