Table 2

Summary of changes in left ventricular ejection fraction (LVEF) seen in clinical trials that have influenced clinical practice based on their significant effect on clinical outcome

∆ LVEF
PCI versus thrombolysis
 Zijlstra et al48PTCA versus streptokinase: 142 patients+6% p=0.004
 Grines et al49PTCA versus rTPA: 395 patients0% p=0.52
 Ribichini et al50PTCA/stent versus rTPA: 110 patients+7.0% p<0.001
ACE inhibitor versus placebo
 SAVE51Captopril versus placebo+1.2% p=0.005
 HEART52Ramipril versus placebo: 352 patients+2.5% p<0.05
β Blockers versus placebo
 CAPRICORN53Carvedilol versus placebo 127 patients+3.9% p=0.015