Cox proportional hazard ratios (95% CI) for the association between alcohol consumption and CHD in men and women of the EPIC Spanish cohort for the different models tested
| Never-drinkers | Former drinkers | Low | Moderate | High | Very high | |
| Men | ||||||
| Cases | 25 | 59 | 69 | 135 | 159 | 33 |
| Basic* | 1.00 | 0.92 (0.57 to 1.47) | 0.66 (0.42 to 1.05) | 0.49 (0.32 to 0.75) | 0.46 (0.30 to 0.71) | 0.49 (0.29 to 0.84) |
| Multivariate† | 1.00 | 0.90 (0.56 to 1.44) | 0.65 (0.41 to 1.04) | 0.49 (0.32 to 0.75) | 0.46 (0.30 to 0.71) | 0.50 (0.29 to 0.85) |
| +Diabetes | 1.00 | 0.89 (0.56 to 1.42) | 0.66 (0.41 to 1.04) | 0.49 (0.32 to 0.76) | 0.47 (0.30 to 0.72) | 0.50 (0.29 to 0.85) |
| +Hyperlipidaemia | 1.00 | 0.85 (0.53 to 1.36) | 0.65 (0.41 to 1.03) | 0.47 (0.31 to 0.73) | 0.44 (0.29 to 0.68) | 0.47 (0.27 to 0.79) |
| +High blood pressure | 1.00 | 0.88 (0.55 to 1.40) | 0.65 (0.41 to 1.03) | 0.49 (0.32 to 0.75) | 0.46 (0.30 to 0.71) | 0.49 (0.29 to 0.83) |
| Women | ||||||
| Cases | 52 | 15 | 38 | 20 | 1 | |
| Basic* | 1.00 | 1.14 (0.64 to 2.01) | 0.72 (0.46 to 1.11) | 0.58 (0.34 to 0.99) | 0.21 (0.03 to 1.52) | |
| Multivariate† | 1.00 | 1.17 (0.66 to 2.08) | 0.75 (0.48 to 1.17) | 0.62 (0.36 to 1.07) | 0.21 (0.03 to 1.52) | |
| +Diabetes | 1.00 | 1.14 (0.64 to 2.02) | 0.78 (0.50 to 1.22) | 0.65 (0.38 to 1.12) | 0.21 (0.03 to 1.51) | |
| +Hyperlipidaemia | 1.00 | 1.16 (0.59 to 1.91) | 0.76 (0.49 to 1.19) | 0.63 (0.36 to 1.08) | 0.20 (0.03 to 1.49) | |
| +High blood pressure | 1.00 | 1.12 (0.63 to 1.98) | 0.73 (0.47 to 1.15) | 0.64 (0.37 to 1.11) | 0.21 (0.03 to 1.54) |
*Basic: model adjusted for centre, smoking status, height and educational level and stratified by age. †Multivariate: model further adjusted by physical activity index, waist/hip ratio, vitamin E, antithrombotic and antihaemorrhagic drugs and energy intake. CHD, coronary heart disease.