HRs (95% CIs) for the association of long-term mortality to baseline MR, LVEF and BNP
| Univariate | p Value | Multivariate model 1 including MR, LVEF and BNP (or MR/LVEF* and BNP) | p Value | Multivariate model 2 including MR or LVEF or BNP or MR/LVEF* + confounders† | p Value | Multivariate model 3 including MR, LVEF and BNP (or MR/LVEF* and BNP) + confounders† | p Value | |
| All-cause mortality | ||||||||
| MR >1.0 | 3.25 (2.41 to 4.37) | <0.0001 | 2.28 (1.67 to 3.12) | <0.0001 | 1.82 (1.29 to 2.59) | 0.0007 | 1.53 (1.06 to 2.19) | 0.02 |
| LVEF <0.40 | 3.48 (2.63 to 4.61) | <0.0001 | 2.38 (1.76 to 3.23) | <0.0001 | 2.34 (1.70 to 3.22) | <0.0001 | 1.94 (1.38 to 2.73) | 0.0001 |
| BNP >373 pmol/l | 2.86 (2.20 to 3.72) | <0.0001 | 1.96 (1.47 to 2.61) | <0.0001 | 1.79 (1.33 to 2.40) | 0.0001 | 1.45 (1.06 to 1.99) | 0.02 |
| MR/LVEF score* | 2.81 (2.33 to 3.38) | <0.0001 | 2.33 (1.90 to 2.85) | <0.0001 | 1.88 (1.51 to 2.34) | <0.0001 | 1.73 (1.38 to 2.17) | <0.0001 |
| Readmission to hospital for CHF | ||||||||
| MR >1.0 | 3.84 (2.52 to 5.86) | <0.0001 | 2.58 (1.66 to 4.01) | <0.0001 | 2.49 (1.56 to 3.96) | 0.0001 | 2.08 (1.29 to 3.35) | 0.003 |
| LVEF <0.40 | 5.14 (3.49 to 7.57) | <0.0001 | 3.54 (2.33 to 5.38) | <0.0001 | 4.14 (2.65 to 6.47) | <0.0001 | 3.41 (2.14 to 5.42) | <0.0001 |
| BNP >373 pmol/l | 3.30 (2.27 to 4.80) | <0.0001 | 2.01 (1.34 to 3.03) | 0.0008 | 2.12 (1.38 to 3.24) | 0.0005 | 1.51 (0.96 to 2.38) | 0.07 |
| MR/LVEF score* | 3.66 (2.82 to 4.74) | <0.0001 | 3.03 (2.29 to 4.02) | <0.0001 | 2.91 (2.15 to 3.94) | <0.0001 | 2.66 (1.94 to 3.65) | <0.0001 |
↵* Per step in 0–1–2 score, where MR grade >1 and LVEF <0.40 were assigned one score point each.
↵† Adjusted for age, gender, smoking, diabetes, hypertension, hypercholesterolaemia and history of diabetes, MI, angina, CHF, PCI/CABG, GFR <60 ml/min and current diagnosis of ACS type.
ACS, acute coronary syndromes; BNP, brain natriuretic peptide; CABG, coronary artery bypass grafting; CHF, congestive heart failure; GFR, glomerular filtration rate; LVEF, left ventricular ejection fraction; MI, myocardial infarction; MR, mitral regurgitation, PCI, percutaneous coronary intervention.