Variables | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
Age, years | 55 | 57 | 59 | 47 | 63 | 52 | 47 | 68 | 42 | 45 | 44 | 28 | 57 |
Sex | F | F | F | F | F | M | F | M | M | F | F | F | M |
Time to symptom onset (months) | 5 | 8 | 13 | 8 | 16 | 12 | 7 | 9 | 6 | 10 | 8 | 7 | 12 |
Flu-like syndrome | Yes | No | No | No | No | No | No | No | Yes | No | No | No | No |
Drug treatment | |||||||||||||
Beta-blockers | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | No | Yes | Yes | No |
Calcium antagonists | No | No | Yes | No | No | Yes | No | Yes | No | Yes | No | No | Yes |
Nitrates | Yes | No | No | Yes | No | No | No | No | No | No | No | Yes | No |
ACE inhibitors | No | Yes | Yes | No | No | Yes | Yes | Yes | Yes | Yes | No | No | Yes |
Statins | No | No | No | No | No | No | No | Yes | No | No | No | No | Yes |
Xanthine derivatives | No | No | Yes | Yes | No | No | No | No | No | No | No | No | No |
Imipramine | Yes | No | No | No | Yes | No | Yes | No | No | No | Yes | Yes | No |
Histology | |||||||||||||
Fibrosis (%) | 6.5 | 6 | 5 | 4.5 | 5.3 | 6.5 | 7.3 | 3.9 | 6.4 | 6.6 | 7.8 | 8 | 5.5 |
Myocyte degeneration | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Focal myocarditis | Yes | No | No | No | No | No | Yes | No | Yes | No | No | No | No |
Viral agent (PCR) | |||||||||||||
Whole myocardial tissue | AV | No | No | No | No | EBV | EBV | EBV | AV/EBV | AV | EBV | HHV-6 | AV |
Laser microdissection | |||||||||||||
Cardiomyocytes | AV | – | – | – | – | EBV | EBV | EBV | AV/EBV | AV | EBV | No | AV |
Small vessels | AV | – | – | – | – | EBV | EBV | EBV | AV/EBV | AV | EBV | HHV-6 | AV |
AV, adenovirus; CSX, cardiac syndrome X; EBV, Epstein–Barr virus; EDD, left ventricular end-diastolic diameter; EF, left ventricular ejection fraction; HHV-6, human herpes virus 6.