Table 3

p Values of UA and MA analyses of potential influencing variables for on-treatment platelet reactivity assessed by LTA and the VerifyNow P2Y12 assay

Maximal aggregation % (LTA)PRU (VerifyNowP2Y12 assay)
VariableUAMAUAMA
CCBs0.0010.0060.0010.004
Statins0.140.480.490.72
PPIs0.40.580.470.77
Age ≥650.250.880.0050.29
Diabetes0.550.780.10.84
Loading dose0.940.790.530.41
Hypertension0.470.980.660.38
Hyperlipidaemia0.180.410.130.14
Creatinine0.210.560.0030.07
C-reactive protein0.70.790.340.4
Smoking0.610.840.020.46
Type of intervention0.310.910.730.29
  • There were no significant differences in clopidogrel-mediated platelet inhibition between patients without and with PPI treatment (p≥0.4 for LTA and the VerifyNow P2Y12 assay).

  • CCBs, calcium-channel blockers; LTA, light transmission aggregometry; MA, multivariate; PPIs, proton pump inhibitors; PRU, P2Y12 reaction units; UA, univariate.