First author | Year | Number of included patients | H-FABP test | Point-of-care test | Prevalence of AMI overall (%) | Duration of symptoms at time of testing (median, minutes) | H-FABP cut-off (ng/ml) | Reference standard | Biomarker used in standard/measurement method diagnostic cut-off |
Alhashemi | 2006 | 64 | Cardiodetect | Yes | 64 | 390 | 7 | ESC/ACC | TnI/not mentioned 0.05 μg/l |
Chen | 2004 | 93 | ELISA | No | 34 | Not known | 16.8 | WHO | CK-MB/corpuscle chemiluminescence (Beckman Coulter) 4.0 μg/l |
Di Serio | 2005 | 30 | Evidence cardiac panel | No | 20 | 204 | 6.4 | ESC/ACC | Troponin, details not provided |
Ecollan | 2006 | 108 | Cardiodetect | Yes | 51 | 139 | 7 | ≈ ESC/ACC | TnI/Stratus CS (Dade Behring) (0.07 μg/l)/0.07 μg/l |
Haastrup | 2000 | 130 | ELISA | No | 16 | 168 | 8 | WHO | CK + CK-MB/Cobas bio (Hoffmann-La Roche) 210 U/l + 20 U/l |
Ilva | 2008 | 293 | ELISA | No | 46 | 282 | 10.4 | ESC/ACC | TnI/Architect STAT (Abbott) (0.032 μg/l)/0.032 μg/l |
Ishii | 1997 | 165 | ELISA | No | 60 | 229 | 12 | ≈ WHO | CK-MB/CK-MB (NAC -activated assay) (Boehringer Mannheim) 24 U/l |
Lefevre | 2007 | 100 | Cardiodetect | Yes | 36 | 354 | 6.2 | ESC/ACC | TnI (measured on 5 sites)/RxL/X Pand (Dade Behring) (0.07 μg/l)(3 sites), Centaur (Siemens) (0.10 μg/l)(2 sites)/0.07 μg/l, 0.10 μg/l |
Mad | 2007 | 280 | Cardiodetect | Yes | 35 | 180 | 7 | ≈ ESC/ACC | TnT/not mentioned 0.04 μg/l |
McCann | 2008 | 415 | ELISA | No | 48 | 300 | 5 | ≈ ESC/ACC | TnT/Elecsys TnT assay (Roche) (<0.01 μg/l)/0.03 μg/l |
Mion | 2007 | 132 | Evidence cardiac panel | No | 32 | 228 | 6.02 | ESC/ACC | TnI/Dimension RxL 0.015 μg/l |
Naroo | 2009 | 791 | Cardiodetect | Yes | 13 | Not known | 7 | ≈ ESC/ACC | TnT/not mentioned 1 μg/l |
Okamoto | 2000 | 189 | ELISA | No | 74 | Not known | 6.2 | WHO | CK-MB/Merck auto CKMB (Kanto Kagaku) 25 U/l |
Seino | 2003 | 371 | Rapicheck | Yes | 49 | Not known | 6.2 | WHO | CK + CK-MB, details not provided |
Seino | 2004 | 129 | Rapicheck | Yes | 24 | Not known | 6.2 | WHO | CK + CK-MB, details not provided |
Valle | 2008 | 419 | Cardiodetect | Yes | 35 | 74 | 7 | ESC/ACC | TnT, details not provided |
ACC, American College of Cardiology; AMI, acute myocardial infarction; CK-MB, creatine kinase-myocardial band; ESC, European Society of Cardiology; NAC, N-acetyl cysteine; TnI, troponin I; TnT, troponin T; WHO, World Health Organization.