Table 1

Plasma ANP molecular forms in normal controls and patients with heart disease

Study	Plasma sample (n)	Diagnosis	Pro-ANP	ANP	Pro-ANP/ANP
Thesis et al13	1	Normal control	None	Major
Akiba et al18	25	Normal control	Minor	Major
Hunter et al12	10, Pooled plasma	Normal control	Equal	Equal
Ohashi et al39	1	Normal control	None	Present
Sato et al40	7, Pooled plasma	Normal control	Minor	Major
Meleagros et al19	1	Normal control	Minor	Major	0.24
Ando et al21	1	Normal control	Minor	Major
Tan et al41	2	Normal control	Minor	Major
Espiner et al42	1	Normal control	Minor	Major
Azizi et al22	Pooled plasma	Normal control	Minor	Major
Yamaji et al14	1	Normal heart, pregnant woman	Minor	Major
Predel et al43	4	CRF, normotension	Minor	Major	0.25
Ishizaka et al15	1	HD, normal heart	Minor	Major	0.47
Cannella et al16	10, pooled	HD, normal heart	Minor	Major
Akiba et al18	10	HD, normal heart	Minor	Major
Hasegawa et al17	1	HD, normal heart	Minor	Major
Lindberg et al44	2	HD, MV stenosis; HD, MI	Minor	Major
Hunter et al12	7, Pooled plasma	HF	Equal	Equal	Pro-ANP=ANP
Yamaji et al14	3, Pooled plasma	HF	Minor	Major
Meleagros et al19	1	HF	Minor	Major	0.16
Mukoyama et al11	1	HF	Minor	Major	Pro-ANP<<ANP
Ando et al21	4	NYHA class I	Minor	Major	0.087
	11	NYHA class II	Minor	Major	0.45
	5	NYHA class III	Major	Minor	1.63
	8	NYHA class IV	Major	Minor	1.27
Azizi et al22	Pooled plasma	HF	Major	Minor	Pro-ANP>>ANP

ANP, atrial natriuretic peptide; CRF, chronic renal failure; HD, haemodialysis; HF, heart failure; Ir, immunoreactive; MI, myocardial infarction; MV, mitral valve; NYHA, New York Heart Association.