Table 4

Identification of patients with CAD versus patients with normal vessels, ≥50% versus <50% stenosis, plaque composition and vascular remodeling by hsTnT

Cut-off point (pg/ml)Sensitivity (%)Specificity (%)PPV (%)NPV (%)AUC
Diagnostic characteristics of hsCRP using optimal cut-off values
Normal vessels versus CAD (any stenosis)1.6548 (36 to 59)67 (51 to 80)71420.55
≥50% vs <50% stenosis1.5175 (51 to 91)58 (48 to 68)26920.61
Detection of non-calcified plaque1.6555 (41 to 70)68 (56 to 79)57670.62
Detection of remodeled plaque1.6589 (52 to 98)62 (52 to 71)16990.75
Detection characteristics of hsTnT using optimal cut-off values
Normal vessels vs CAD (any stenosis)10.063 (51 to 73)83 (69 to 92)86560.73
≥50% vs <50% stenosis12.660 (36 to 81)68 (55 to 79)39840.63
Detection of non-calcified plaque10.570 (55 to 82)85 (74 to 92)77790.79
Detection of remodeled plaque21.878 (40 to 97)98 (94 to 99)78980.90
Detection characteristics of hsTnT using a cut-off value of 14 pg/ml
Normal vessels vs CAD (any stenosis)14.033 (22 to 44)98 (88 to 99)96460.73
≥50% vs <50% stenosis14.040 (19 to 64)70 (57 to 81)31780.63
Detection of non-calcified plaque14.043 (30 to 58)97 (90 to 99)92700.79
Detection of remodeled plaque14.078 (40 to 97)85 (77 to 91)29980.90
  • Data are presented as numbers (for cut-off values and areas under the curves (AUC)) and as percentages for all other variables. For sensitivity and specificity 95% CIs are also given.

  • AUC, area under the curve; CAD, coronary artery disease; hsCRP, high sensitive C-reactive protein; hsTnT, high sensitive troponin; NPV, negative predictive value; PPV, positive predictive value.