Table 2

Meta-analysis of relationship between testosterone and cardiovascular disease in healthy men.

StudiesNoRR (95% CI)p Value*
Total testosterone180.89 (0.83 to 0.96)0.00
 Age of study population <70 years71.01 (0.95 to 1.08)0.41
 Including men >70 years110.84 (0.76 to 0.92)0.00
 Year of publication before 1 January 200760.97 (0.94 to 1.00)0.08
 After 1 January 200750.77 (0.72 to 0.82)0.81
Free testosterone70.88 (0.78 to 1.00)0.00
 Age of study population <70 years30.99 (0.90 to 1.09)0.11
 Including men >70 years40.84 (0.71 to 1.00)0.00
 Year of publication before 1 January 200720.95 (0.91 to 1.00)0.63
 After 1 January 200720.77 (0.72 to 0.82)0.65
Bioavailable testosterone (men>70 years)30.74 (0.62 to 0.88)0.71
  • Estimated summary RRs are provided for a change of 1 SD of testosterone level (high vs low), with the help of random-effects model RRs (95% CI).

  • * p Value of heterogeneity.