Table 2

Pooled outcome estimates*

Type of surgeryReintervention (%/year)Thrombo-embolic event (%/year)Endocarditis (%/year)Composite valve-related event (%/year)
Groenink10 1999TRR0.6 (−0.2 to 1.5)NRNR
Gott11 1999TRR0.2 (0.1 to 0.4)0.7 (0.4 to 0.9)0.6 (0.4 to 0.8)1.5 (1.1 to 1.8)
Alexiou12 2001TRR0.2 (−0.2 to 0.6)1.0 (0.1 to 1.9)0.2 (−0.2 to 0.6)1.3 (0.3 to 2.3)
de Oliveira13 2003TRR1.9 (0.2 to 3.5)0.7 (−0.3 to 1.8)1.1 (−0.1 to 2.4)3.6 (1.4 to 5.9)
Karck14 2004TRR0.9 (0.2 to 1.6)0.8 (0.1 to 1.4)0.3 (−0.1 to 0.7)1.8 (0.8 to 2.9)
Zehr15 2005TRR0.4 (−0.2 to 0.6)1.1 (0.1 to 2.0)0.2 (−0.2 to 0.6)0.2 (−0.2 to 0.6)
Patel16 2008TRR0.2 (−0.2 to 0.6)0.9 (0.1 to 1.8)0.1 (−0.2 to 0.4)1.1 (0.2 to 2.0)
Birks17 1999VSRR2.6 (1.1 to 4.1)0.2 (−0.2 to 0.7)0.2 (−0.2 to 0.7)2.9 (1.3 to 4.5)
Gott11 1999VSRR0.3 (−0.3 to 0.9)0.3 (0.3 to 0.9)0.1 (−0.3 to 0.6)0.6 (−0.2 to 1.4)
Kallenbach18 2007VSRR2.6 (0.7 to 4.6)0.4 (−0.4 to 1.1)0.2 (0.3 to 0.7)3.0 (0.9 to 5.1)
Settepani19 2007VSRR5.4 (−0.7 to 11.6)0.9 (−1.6 to 3.4)1.8 (−1.7 to 5.4)7.2 (0.1 to 14.3)
Patel16 2008VSRR2.4 (0.3 to 4.5)0.5 (−0.5 to 1.4)0.2 (−0.4 to 0.9)2.9 (0.6 to 5.1)
David20 2009VSRR0.4 (−0.1 to 0.9)0.4 (−0.1 to 0.9)0.1 (−0.1 to 0.4)0.9 (0.2 to 1.6)
Overall TRR0.3 (0.1 to 0.5)0.7 (0.5 to 0.9)0.3 (0.2 to 05)1.3 (0.6 to 2.0)
Overall VSRR1.3 (0.3 to 2.2)0.3 (0.1 to 0.6)0.2 (−0.0 to 0.3)1.9 (0.8 to 2.9)
Heterogeneity testTRRχ2 7.8 (p=NS)χ2 1.4 (p=NS)χ2 10.1 (p=NS)χ2 30.0 (p<0.001)
I2=24%I2=0%I2=50%I2=83%
VSRRχ2 17.6 (p=0.004)χ2 0.6 (p=NS)χ2 1.02 (p=NS)χ2 14.7 (p=0.01)
I2=71%I2=0%I2=0%I2=66%
Total Betweenχ2 4.8 (p=0.02)χ2 5.6 (p=0.01)χ2 1.9 (p=NS)χ2 0.6 (p=NS)
  • * Rates are reported with their relative 95% CI.

  • could not be calculated.

  • NR, not reported; NS, not significant; TRR, total root replacement; VSRR, valve-sparing root replacement.