Characteristic | Total population (n=352) | Patients with major bleeding (n=19 (5.4%)) | Patients without major bleeding (n=333 (94.6%)) | p Value |
Age (mean) | 65.04±12.16 | 69.95±11.71 | 64.76±12.14 | 0.08 |
Female | 100 (28.4%) | 6 (31.6%) | 94 (28.2%) | 0.75 |
Weight (kg) | 76.47±15.46 | 73.83±14.74 | 76.61±15.51 | 0.33 |
Medical history | ||||
Current smoking | 116 (33%) | 5 (26.3%) | 111 (33.3%) | 0.53 |
Diabetes | 95 (27%) | 4 (21.1%) | 91 (27.3%) | 0.55 |
Dyslipidaemia | 202 (57.4%) | 9 (47.4%) | 193 (58%) | 0.37 |
Hypertension | 223 (63.4%) | 12 (63.2%) | 211 (63.4%) | 0.99 |
Previous CABG | 21 (6%) | 1 (5.3%) | 20 (6%) | 1.0 |
Previous MI | 62 (17.6%) | 4 (21.1%) | 58 (17.4%) | 0.76 |
Previous PCI | 97 (27.6%) | 5 (26.3%) | 92 (27.6%) | 0.95 |
Cardiac insufficiency | 14 (4%) | 1 (5.3%) | 13 (3.9%) | 0.55 |
Entry criteria | ||||
Ischaemic symptom | 345 (98%) | 19 (100%) | 326 (97.9%) | 1.0 |
ST segment or T wave segment change | 258 (73.3%) | 13 (68.4%) | 245 (73.6%) | 0.62 |
Increased troponin I | 261 (74.1%) | 17 (89.5%) | 244 (73.3%) | 0.17 |
TIMI score | 3.91±1.05 | 4.32±1 | 3.89±1.05 | 0.06 |
Physical examination | ||||
Heart rate (beats/min) | 74±15 | 72±12 | 74±15 | 0.75 |
Systolic blood pressure (mm Hg) | 147±25 | 142±20 | 147±25 | 0.40 |
Diastolic blood pressure (mm Hg) | 79±14 | 75±12 | 79±14 | 0.31 |
Laboratory findings | ||||
Creatinine on admission (μmol/l) | 85±46 | 123±150 | 83±31 | 0.05* |
Peak creatinine during hospital stay (μmol/l) | 97±57 | 170±169 | 92.81±39 | 0.005* |
Peak troponin (ng/ml) | 7.4±15.6 | 8.5±15.4 | 7.38±15.65 | 0.28 |
Values are mean±SD or number (%).
↵* p<0.05.
CABG, coronary artery bypass graft; MI, myocardial infarction; PCI, percutaneous coronary intervention; TIMI, thrombolysis in myocardial infarction.