Clinical characteristics of patients undergoing TAVI according to the occurrence of at least moderate post-procedural AR
| Characteristics | AR≥2/4 (n=119) | AR<2/4 (n=571) | p Value | OR (95% CI) |
| Age (years) | 81.1±6.3 | 81.4±6.4 | 0.72 | – |
| Male gender | 68 (57) | 239 (42) | 0.002 | 1.85 (1.24 to 2.76) |
| Weight (kg) | 74.8±16.2 | 73.6±16.2 | 0.48 | – |
| Height (cm) | 166±11.4 | 166±8.8 | 0.37 | – |
| BMI (kg/m2) | 28.4±20.2 | 26.8±6.8 | 0.86 | – |
| Cardiogenic shock/decompensation | 42 (35) | 135 (24) | 0.01 | 1.74 (1.14 to 2.65) |
| Pulmonary hypertension | 85 (72) | 340 (61) | 0.02 | 1.67 (1.08 to 2.59) |
| Atrial fibrillation | 33 (28) | 124 (22) | 0.17 | 1.37 (0.88 to 2.15) |
| Diabetes mellitus | 38 (32) | 201 (35) | 0.46 | 0.85 (0.56 to 1.30) |
| Previous MI | 23 (20) | 90 (16) | 0.32 | 1.30 (0.78 to 2.16) |
| Coronary artery disease | 75 (64) | 336 (59) | 0.40 | – |
| Three-vessel disease | 42 (36) | 138 (24) | 0.01 | 1.71 (1.12 to 2.62) |
| Left main disease | 6 (5.1) | 33 (5.9) | 0.74 | 0.86 (0.35 to 2.11) |
| Previous cardiac surgery | 38 (32) | 125 (22) | 0.02 | 1.66 (1.08 to 2.56) |
| Peripheral arterial disease | 24 (20) | 94 (17) | 0.34 | 1.27 (0.77 to 2.09) |
| Aortic aneurysm | 6 (5) | 10 (1.8) | 0.03 | 2.96 (1.05 to 8.30) |
| Previous stroke | 12 (10) | 43 (7.6) | 0.35 | 1.37 (0.70 to 2.68) |
| Renal failure* | 62 (56) | 360 (63) | 0.02 | 0.64 (0.43 to 0.95) |
| COPD | 35 (29) | 137 (24) | 0.23 | 1.31 (0.85 to 2.03) |
| Logistic Euroscore (%) | 24±15.6 | 19.6±12.5 | 0.01 | – |
| ASA physical status class | ||||
| 1=normal healthy patient | 0 (0) | 13 (2.3) | 0.09 | – |
| 2=patient with mild systemic disease | 38 (32) | 180 (32) | 0.96 | 1.01 (0.66 to 1.55) |
| 3=patient with severe systemic disease (limits function but is not incapacitating) | 65 (55) | 294 (52) | 0.57 | 1.12 (0.75 to 1.67) |
| 4=patient with severe systemic disease that is a constant threat to life | 12 (10) | 71 (13) | 0.46 | 0.78 (0.41 to 1.50) |
| 5=moribund patient | 3 (2.5) | 5 (0.9) | 0.12 | 2.91 (0.69 to 12.35) |
| NYHA functional class | ||||
| 0/I | 1 (0.9) | 10 (1.8) | 0.47 | 0.48 (0.06 to 3.78) |
| II | 7 (6) | 61 (11) | 0.11 | 0.53 (0.23 to 1.18) |
| III | 82 (70) | 400 (71) | 0.89 | 0.97 (0.63 to 1.50) |
| IV | 27 (23) | 95 (17) | 0.11 | 1.49 (0.92 to 2.41) |
Values are n (%) or mean±SD.
↵* Defined as glomerular filtration rate <60 ml/min/1.73 m2.
AR, aortic regurgitation; ASA, American Society of Anesthesiologists; BMI, body mass index; COPD, chronic obstructive pulmonary disease; MI, myocardial infarction; NYHA, New York Heart Association; TAVI, transcatheter aortic valve implantation.