Table 2

Pregnancy loss and risk of myocardial infarction

	Myocardial infarction
	No	Yes	Age-adjusted		Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	n	n	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Miscarriage
Continuous			1.42	1.14 to 1.78	1.25	0.94 to 1.65	1.23	0.93 to 1.63	1.26	0.94 to 1.69	1.27	0.95 to 1.71	1.27	0.94 to 1.70	1.27	0.95 to 1.70
No	8216	53	1.00
Yes	2725	26	1.42	0.88 to 2.30	1.07	0.63 to 1.82	1.04	0.61 to 1.76	1.16	0.67 to 2.00	1.19	0.69 to 2.05	1.18	0.69 to 2.04	1.18	0.69 to 2.04
1–3 versus 0	2656	22	1.23	0.74 to 2.04	1.02	0.59 to 1.77	0.98	0.56 to 1.70	1.12	0.64 to 1.96	1.14	0.65 to 2.00	1.14	0.65 to 2.00	1.14	0.65 to 1.99
>3 versus 0	59	4	8.90	3.18 to 24.90	5.01	1.45 to 17.33	4.98	1.43 to 17.29	4.75	1.19 to 19.05	4.93	1.22 to 19.86	4.98	1.24 to 20.04	5.06	1.26 to 20.29
Abortion
Continuous			1.05	0.70 to 1.57	0.83	0.54 to 1.27	0.82	0.54 to 1.26	0.87	0.57 to 1.31	0.86	0.57 to 1.30	0.86	0.57 to 1.30	0.86	0.57 to 1.29
No	9011	69
Yes	1938	10	1.11	0.55 to 2.26	0.80	0.38 to 1.72	0.77	0.37 to 1.64	0.88	0.41 to 1.89	0.87	0.41 to 1.87	0.88	0.41 to 1.89	0.87	0.41 to 1.88
1–3 versus 0	1880	10	1.17	0.57 to 2.37	0.87	0.41 to 1.84	0.84	0.40 to 1.76	0.96	0.45 to 2.04	0.95	0.45 to 2.02	0.96	0.45 to 2.04	0.96	0.45 to 2.04
>3 versus 0	53	0	NC		NC		NC		NC		NC		NC		NC
Stillbirth
Continuous			2.65	1.37 to 5.12	2.15	1.08 to 4.26	2.05	1.05 to 4.01	2.24	1.16 to 4.31	2.39	1.23 to 4.67	2.39	1.23 to 4.64	2.32	1.19 to 4.50
No	10 762	72
Yes	190	7	3.70	1.69 to 8.11	2.91	1.30 to 6.53	2.88	1.28 to 6.47	3.42	1.52 to 7.71	3.46	1.54 to 7.78	3.49	1.55 to 7.84	3.43	1.53 to 7.72

Model 1: Adjusted for age, total number of pregnancies and education.
Model 2: Adjusted for above-mentioned variables plus smoking, alcohol and physical activity.
Model 3: Adjusted for variables in models 1 and 2 plus body mass index and waist to hip ratio.
Model 4: Adjusted for variables in models 1, 2 and 3 plus hypertension.
Model 5: Adjusted for all above-mentioned variables plus diabetes mellitus.
Model 6: Adjusted for above-mentioned variables plus hyperlipidaemia.
Bold HR, statistically significant.
HR, hazard ratio; NC, not calculable.