Table 3

Pregnancy loss and risk of stroke

	Stroke
	No	Yes	Age-adjusted		Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	n	n	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Miscarriage
Continuous			0.92	0.67 to 1.25	0.87	0.61 to 1.22	0.86	0.61 to 1.22	0.90	0.63 to 1.29	0.91	0.64 to 1.29	0.91	0.64 to 1.29	0.91	0.64 to 1.29
No	8196	86
Yes	2733	21	0.75	0.46 to 1.23	0.69	0.40 to 1.18	0.68	0.40 to 1.16	0.71	0.41 to 1.23	0.72	0.42 to 1.25	0.72	0.42 to 1.25	0.72	0.42 to 1.25
1–3 versus 0	2663	20	0.74	0.45 to 1.21	0.68	0.45 to 1.21	0.67	0.39 to 1.15	0.70	0.40 to 1.23	0.70	0.40 to 1.23	0.72	0.41 to 1.25	0.72	0.41 to 1.25
>3 versus 0	60	1	1.66	0.23 to 11.97	1.29	0.16 to 10.44	1.28	0.16 to 10.29	1.34	0.17 to 10.95	1.34	0.17 to 10.95	1.30	0.16 to 10.64	1.31	0.161 to 0.65
Abortion
Continuous			1.12	0.82 to 1.54	1.12	0.79 to 1.60	1.10	0.78 to 1.56	1.14	0.80 to 1.61	1.13	0.80 to 1.60	1.14	0.81 to 1.61	1.14	0.81 to 1.61
No	9001	90
Yes	1936	17	1.26	0.73 to 2.18	1.27	0.71 to 2.26	1.22	0.68 to 2.17	1.32	0.73 to 2.37	1.33	0.74 to 2.39	1.34	0.74 to 2.40	1.33	0.74 to 2.40
1–3 versus 0	1880	16	1.22	0.70 to 2.14	1.24	0.69 to 2.24	1.19	0.66 to 2.15	1.29	0.71 to 2.35	1.30	0.72 to 2.37	1.31	0.72 to 2.38	1.31	0.72 to 2.38
>3 versus 0	50	1	2.71	0.38 to 19.61	2.81	0.34 to 22.90	2.57	0.32 to 20.60	2.70	0.33 to 21.84	2.69	0.33 to 21.85	2.76	0.34 to 22.42	2.73	0.34 to 22.27
Stillbirth
Continuous			1.62	0.65 to 4.07	1.59	0.62 to 4.03	1.47	0.58 to 3.74	1.57	0.63 to 3.93	1.57	0.62 to 4.02	1.57	0.62 to 4.00	1.57	0.62 to 3.99
No	10 748	102
Yes	192	5	1.87	0.69 to 5.12	1.83	0.66 to 5.10	1.70	0.61 to 4.74	1.89	0.68 to 5.28	1.81	0.65 to 5.05	1.82	0.65 to 5.06	1.81	0.65 to 5.05

Model 1: Adjusted for age, total number of pregnancies and education.
Model 2: Adjusted for above-mentioned variables plus smoking, alcohol and physical activity.
Model 3: Adjusted for variables in models 1 and 2 plus body mass index and waist to hip ratio.
Model 4: Adjusted for variables in models 1, 2 and 3 plus hypertension.
Model 5: Adjusted for all above-mentioned variables plus diabetes mellitus.
Model 6: Adjusted for above-mentioned variables plus hyperlipidaemia.
HR, hazard ratio.