Variables | Single variable models | Multivariable model | ||
HR (95% CI) | Sig. | HR (95% CI) | Sig. | |
Age, 10 years | 1.345 (1.106 to 1.635) | 0.003 | 0.8 | |
Gender | 1.245 (0.677 to 2.288) | 0.48 | ||
Mean pulmonary artery pressure, mm Hg | 1.015 (0.984 to 1.046) | 0.35 | ||
Pulmonary capillary wedge pressure, mm Hg | 0.931 (0.813 to 1.065) | 0.30 | ||
Mean right atrial pressure, mm Hg | 1.058 (1.001 to 1.117) | 0.045 | 0.4 | |
ln[cardiac index, l/min/m2] | 0.377 (0.142 to 1.006) | 0.051 | 0.7 | |
Pulmonary vascular resistance, Woods units | 1.041 (1.000 to 1.085) | 0.053 | 0.4 | |
WHO at sampling | 2.143 (1.383 to 3.320) | 0.001 | 0.2 | |
Six minute walk, 100 m | 0.637 (0.519 to 0.782) | <0.001 | 0.714 (0.569 to 0.896) | 0.004 |
Treatments | 0.919 (0.649 to 1.301) | 0.63 | ||
Treated versus untreated | 0.590 (0.328 to 1.062) | 0.078 | 0.1 | |
Years since diagnosis sampled | 1.039 (1.016 to 1.062) | 0.001 | 0.1 | |
Red cell distribution width, % | 1.142 (1.054 to 1.238) | 0.001 | 1.274 (1.147 to 1.416) | <0.001 |
ln[growth differentiation factor, pg/ml] | 1.961 (1.401 to 2.743) | <0.001 | 0.3 | |
ln[interleukin-6, pg/ml] | 1.652 (1.286 to 2.123) | <0.001 | 0.3 | |
ln[creatinine, μmol/l] | 14.52 (4.256 to 49.52) | <0.001 | 0.4 | |
Square root[N-terminal pro-brain natriuretic peptide, fmol/ml] | 1.038 (1.018 to 1.058) | <0.001 | 1.044 (1.020 to 1.069) | <0.001 |
Individual variables associations with survival were first analysed. Variables with p<0.1 were then further analysed in a multivariable approach to identify independent prognostic variables.