Clinical outcomes since baseline at 12, 24 and 36-month follow-ups in patients included in the REACH Registry Europe according to ‘good control’ or ‘poor control’ of their cardiovascular risk factors
| Follow-up | 12 Months | 24 Months | 36 Months | |||
| Good control | Poor control | Good control | Poor control | Good control | Poor control | |
| No of patients | 11 765 (59.6%) | 7975 (40.4%) | 11 415 (59.7%) | 7694 (40.2%) | 9539 (60.4%) | 6238 (39.5%) |
| Mortality since baseline (%) | 2.8 | 2.7 | 5.1 | 5.0 | 9.7 | 10.8* |
| % Non-cardiovascular death of total mortality (%) | 30.6 | 23.8 | 33.0 | 29.8 | 33.0 | 31.3 |
| Cardiovascular death (%) | 1.9 | 2.0 | 3.4 | 3.5 | 6.4 | 7.1 |
| Fatal MI (%) | 0.4 | 0.5 | 0.8 | 1.0 | 1.4 | 2.0* |
| Fatal stroke (%) | 0.3 | 0.4 | 0.5 | 0.8 | 1.2 | 1.6* |
| Non-fatal stroke (%) | 1.7 | 2.4*** | 2.8 | 4.2**** | 5.1 | 7.7**** |
| Non-fatal MI (%) | 1.1 | 1.4* | 1.8 | 2.3* | 3.2 | 4.4*** |
| cMACCE (%) | 4.5 | 5.6*** | 7.5 | 9.1*** | 13.4 | 16.9**** |
| Hospitalisation (%) | 14.0 | 16.9**** | 19.2 | 22.7**** | 29.3 | 36.0**** |
| cMACCE/hospitalised (%) | 15.6 | 18.8**** | 22.8 | 26.4**** | 34.6 | 41.7**** |
| PAD: worsening of claudication related to PAD (%) | 4.2 | 6.3**** | 6.4 | 9.6**** | 10.4 | 16.8**** |
| Other outcomes leading to hospitalisation | ||||||
| Unstable angina (%) | 5.5 | 6.0 | 9.0 | 9.3 | 14.9 | 17.3*** |
| TIA (%) | 1.3 | 3.2**** | 2.4 | 5.5**** | 4.4 | 10.1**** |
| Other ischaemic arterial event (%) | 1.8 | 2.4** | 2.7 | 3.9**** | 5.0 | 7.2**** |
| Vascular interventions since baseline | ||||||
| CABG (%) | 1.2 | 1.1 | 1.8 | 1.7 | 2.9 | 3.3 |
| Coronary angioplasty/stenting (%) | 3.1 | 2.7 | 4.9 | 4.3 | 8.6 | 8.5 |
| Carotid surgery (%) | 0.4 | 0.8** | 0.6 | 1.1** | 1.2 | 1.9*** |
| Carotid angioplasty/stenting (%) | 0.3 | 0.5** | 0.4 | 0.7* | 0.8 | 1.3** |
| Amputation affecting lower limb (%) | 0.3 | 0.6** | 0.6 | 1.0*** | 0.9 | 1.9**** |
| Peripheral bypass graft (%) | 1.0 | 1.7**** | 1.4 | 2.4**** | 2.3 | 4.5**** |
| Other interventions for PAD (%) | 1.3 | 1.9** | 2.1 | 3.0*** | 3.6 | 5.7**** |
| Total revascularisations since baseline (%) | 6.8 | 8.0** | 10.2 | 11.9*** | 16.7 | 20.7**** |
| Coronary revascularisations (%) | 4.1 | 3.7 | 6.5 | 5.8 | 10.9 | 11.1 |
| Carotid revascularisations (%) | 0.6 | 1.1*** | 1.0 | 1.6**** | 1.7 | 3.0**** |
| Peripheral revascularisations (%) | 2.3 | 3.7**** | 3.5 | 5.6**** | 5.6 | 9.9**** |
| cMACCE and/or revascularisation (%) | 10.5 | 12.4**** | 16.0 | 18.8**** | 26.2 | 31.8**** |
Cardiovascular risk factors are considered controlled when at the following target levels: systolic blood pressure <140 mm Hg, diastolic blood pressure <90 mm Hg, glycaemia <1.1 g/l, total cholesterol <2.0 g/l, non-smoking; ‘good control’, 3-5 risk factors at target; ‘poor control’, 0–2 risk factors at target.
*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, versus good control group.
CABG, coronary artery bypass grafting; cMACCE, cardiovascular death/non-fatal stroke/non-fatal myocardial infarction; MI, myocardial infarction; PAD, peripheral artery disease; TIA, transient ischaemic attack.