Table 3

Association of PTH with secondary cardiovascular events and all-cause mortality in Cox proportional hazards models

OutcomePTH categoriesHR (95% CI)
pg/mlTotal numberNo of eventsModel 1*Model 2Model 3Model 4§Model 5
Cardiovascular events
Quartile modelQ1: <262292911111
Q2: 26–<34276340.99 (0.60–1.62)0.92 (0.55–1.54)0.98 (0.55–1.72)0.92 (0.55–1.54)0.94 (0.56–1.58)
Q3: 34–<44275391.11 (0.68–1.79)1.03 (0.62–1.70)1.13 (0.65–1.96)1.00 (0.60–1.66)1.00 (0.60–1.66)
Q4: ≥44259511.55 (0.98–2.45)1.41 (0.87–2.29)1.69 (0.97–2.95)1.39 (0.86–2.26)1.16 (0.70–1.91)
Continuous (per 1 SD–increase)**10391531.35 (1.21–1.51)1.30 (1.15–1.48)1.37 (1.18–1.59)1.28 (1.13–1.46)1.18 (1.03–1.35)
All-cause-mortality
Quartile modelQ1: <262541811111
Q2: 26–<34294321.57 (0.88–2.79)1.63 (0.88–3.01)2.00 (0.98–4.07)1.65 (0.89–3.06)1.64 (0.89–3.04)
Q3: 34–<44300371.68 (0.96–2.96)1.88 (1.03–3.43)2.42 (1.21–4.84)1.85 (1.01–3.38)1.87 (1.02–3.41)
Q4: ≥44285371.73 (0.98–3.04)1.52 (0.83–2.81)2.02 (0.97–4.24)1.51 (0.82–2.79)1.23 (0.66–2.31)
Continuous (per 1 SD–increase)**11331241.25 (1.11–1.42)1.21 (1.05–1.40)1.20 (1.02–1.42)1.19 (1.03–1.37)1.10 (0.94–1.29)
  • * Model 1: adjusted for age and sex.

  • Model 2 (‘fully adjusted model’): adjusted for established cardiovascular risk factors (age, sex, hypertension, diabetes, smoking, body mass index, total cholesterol, high-density lipoprotein, triglycerides, use of diuretics, ACE inhibitors, β-blockers, calcium antagonists, lipid-lowering drugs, history of myocardial infarction, number of affected vessels).

  • Model 3: Model 2 plus factors associated with mineral metabolism (calcium, albumin, phosphate, vitamin D, creatinine clearance, season of blood draw).

  • § Model 4: Model 2 plus potential intermediator C-reactive protein (inflammation).

  • Model 5: Model 2 plus potential intermediator N-terminal pro brain natriuretic peptide (ventricular dysfunction).

  • ** 1 SD=18.62 pg/ml.

  • PTH, parathyroid hormone.