Table 3

Percentage of the variability in on-treatment platelet reactivity explained

5 μmol/l ADP-induced LTA20 μmol/l ADP-induced LTAPlateletWorksVerifyNow P2Y12
R2p ValueR2p ValueR2p ValueR2p Value
CYP2C19*25.0%<0.0016.2%<0.0014.4%<0.0013.7%<0.001
Clinical variables*8.9%<0.0019.8%<0.0012.9%0.51517.3%<0.001
CYP2C19*2 + clinical variables13.0%<0.00115.2%<0.0015.6%0.05820.6%<0.001
p for change<0.001<0.0010.839<0.001
  • The percentage of the variability in on-treatment platelet reactivity explained was defined as the coefficient of determination (R2). 100%.

  • * Clinical variables included were those significantly associated with on-treatment platelet reactivity in univariate analysis.

  • p Value for the change in R2 when adding clinical variables to CYP2C19*2 genotype.

  • LTA, light transmittance aggregometry.