Parameters | Follow-up patients without HFNEF | Follow-up patients with HFNEF | p Value |
Heart dimensions | |||
LVEF, Simpson (%) | 64.0 (63.0–68.0) | 64.0 (59.0–68.0) | 0.42 |
LA parasternal, mm | 38.0 (37.0–40.0) | 36.5 (33.0–42.0) | 0.33 |
LVEDD, mm | 52.0 (49.0–55.0) | 49.0 (45.0–52.0) | 0.05 |
LVESD, mm | 32.0 (27.0–35.0) | 31.0 (27.0–33.5) | 0.48 |
Septum, mm | 11.0 (10.0–11.0) | 10.0 (9.0–11.5) | 0.57 |
Posterior wall, mm | 11.0 (10.0–11.0) | 11.0 (9.0–11.0) | 0.57 |
LVOT, m/s | 1.0 (0.92–1.10) | 1.0 (0.95–1.13) | 0.79 |
Conventional Doppler | |||
E, m/s | 0.7 (0.63–0.84) | 0.81 (0.71–0.94) | 0.16 |
A, m/s | 0.61 (0.47–0.7) | 0.84 (0.74–0.99) | 0.001 |
E/A | 1.12 (1.03–1.42) | 0.97 (0.81–1.18) | 0.012 |
IVRT, ms | 85.6 (73.9–95.6) | 102.7 (91.3–107.9) | 0.0024 |
DT, ms | 205 (180–216) | 241 (205–255) | 0.02 |
Tissue Doppler | |||
Slateral, m/s | 0.08 (0.06–0.09) | 0.07 (0.05–0.08) | 0.09 |
E′lateral, m/s | 0.09 (0.08–0.11) | 0.07 (0.06–0.08) | 0.006 |
A′lateral, m/s | 0.07 (0.05–0.09) | 0.07 (0.06–0.08) | 0.9 |
E′/A′lateral | 1.43 (0.87–1.95) | 0.92 (0.61–1.3) | 0.03 |
E/E′lateral | 7.9 (6.9–8.9) | 9.4 (8.3–16.9) | 0.006 |
S′septal, m/s | 0.06 (0.06–0.07) | 0.06 (0.05–0.06) | 0.07 |
E′septal, m/s | 0.09 (0.08–0.11) | 0.07 (0.06–0.09) | 0.03 |
A′septal, m/s | 0.07 (0.06–0.09) | 0.07 (0.07–0.08) | 0.9 |
E′/A′septal | 1.19 (0.98–1.45) | 0.9 (0.75–1.25) | 0.04 |
E/E′septal | 6.8 (6.4–9.1) | 10.9 (9.3–13.8) | 0.001 |
E/E′mean | 7.4 (6.8–9.8) | 10.8 (9.5–14.4) | 0.001 |
Values are expressed as the median (25–75% quartile).
A′, late diastolic velocity; DT, deceleration time; E′, early diastolic peak velocity; E/A, ratio of peak early and late mitral flow; E/E′, ratio of transmitral flow velocity to annular velocity; HFNEF, heart failure with a normal ejection fraction; IVRT, isovolumic relaxation time; LA, left atrium; LVEDD, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; LVOT, left ventricular outflow tract; S′, systolic peak velocity.