Baseline characteristics
| Total (n=370) | Death in hospital (n=15) | Death at 1 year (n=39) | |
| Age (years) | 71 (59–78) | 76 (75–86)* | 84 (75–89)* |
| Male sex | 273 (73.8) | 11 (73.3) | 27 (69.2) |
| Hypertension | 293 (79.2) | 14 (93.3) | 34 (87.2) |
| Hypercholesterolaemia | 223 (60.3) | 7 (46.7) | 19 (48.7) |
| Diabetes | 102 (27.6) | 6 (40.0) | 15 (38.5) |
| Body mass index (kg/m2) | 27.0±4.4 | 25.7±4.2 | 25.3±4.1* |
| Family history (1st degree) | 68 (38.9) | 3 (50.0) | 3 (33.3) |
| Smoking | 89 (24.2) | 4 (26.7) | 11 (28.2) |
| Risk factors ≥2 | 272 (73.5) | 11 (73.3) | 26 (66.7) |
| Past myocardial infarction | 148 (40.0) | 4 (26.7) | 20 (51.3) |
| Past coronary artery disease | 209 (56.5) | 9 (60.0) | 29 (74.4)* |
| Known renal failure | 58 (15.7) | 5 (33.3) | 19 (48.7)* |
| Drug regimen | |||
| Aspirin | 213 (57.6) | 8 (53.3) | 21 (53.9) |
| Clopidogrel | 64 (17.3) | 0 (0) | 7 (18.0) |
| β-adrenergic blocker | 187 (50.5) | 6 (40.0) | 24 (61.5) |
| ACE inhibitor/ARB | 200 (54.1) | 11 (73.3) | 25 (64.1) |
| Statin | 188 (50.8) | 6 (40.0) | 22 (56.4) |
| Duration of chest pain (h) | 4.5±3.2 | 4.4±2.7 | 5.0±3.8 |
| Clinical presentation | |||
| Heart rate on admission (beats/min) | 77±18 | 91±33* | 89±25* |
| Systolic BP (mm Hg) | 145±26 | 140±36 | 134±33* |
| Diastolic BP (mm Hg) | 83±15 | 85±22 | 78±21* |
| ST segment deviation | 151 (40.8) | 11 (73.3)* | 33 (84.6)* |
| Screening blood tests | |||
| Creatinine (μmol/l) | 91±46 | 108±41 | 118±48* |
| GFR (ml/min/1.73 m2) | 82±27 | 65±21* | 60±26* |
| Haemoglobin (g/dl) | 140±18 | 139±15 | 125±23 |
| cTn >99th centile | 192 (77.7) | 7 (47.7) | 26 (66.7)* |
| hs-cTn (ng/l) | 28 (10–121) | 78 (27–224)* | 147 (30–470)* |
| hs-cTn >99th centile | 237 (67.9) | 14 (93.3)* | 36 (92.3)* |
| BNP (pg/ml) | 139 (64–369) | 487 (229–885)* | 558 (322–1183)* |
| Coronary angiography | 250 (67.6) | 8 (53.3) | 16 (41.0)* |
| PCI | 177 (47.8) | 4 (26.7) | 10 (25.6)* |
| Coronary artery bypass grafting | 34 (9.2) | 3 (20.0) | 3 (7.7) |
Data are presented as mean±SD or median (IQR) or number (%).
* p<0.05 for patients with versus without end point.
ARB, angiotensin II receptor blocker; BNP, B-type natriuretic peptide; BP, blood pressure; GFR, glomerular filtration rate; PCI, percutaneous coronary intervention; ACE, angiotensin converting enzyme; hs-cTn: high-sensitive cardiac troponin.