Cox proportional hazard model (multivariate analysis) considering both primary and secondary end points
| Primary end point (death or hospitalisation) | χ2 | HR (95% CI) | p Value |
| Age >65 (yes-no) | 16 | 1.6 (1.3 to 2.1) | <0.0001 |
| NYHA class III-IV vs I-II | 39 | 2.1 (1.7 to 2.7) | <0.0001 |
| Severe FMR (yes-no) | 11 | 1.5 (1.2 to 1.9) | 0.001 |
| RMP (yes-no) | 9 | 1.4 (1.1 to 1.8) | 0.003 |
| LVEF <30% (yes-no) | 8 | 1.4 (1.1 to 1.8) | 0.004 |
| All-cause mortality | |||
| Age >65 (yes-no) | 17 | 2.1 (1.5 to 2.9) | <0.0001 |
| NYHA class III-IV vs I-II | 25 | 2.3 (1.7 to 3.2) | <0.0001 |
| Severe FMR (yes-no) | 7 | 1.5 (1.1 to 2.1) | 0.009 |
| RMP (yes-no) | 17 | 2.0 (1.5 to 3.0) | <0.0001 |
| <LVEF<30% (yes-no) | 12 | 1.8 (1.3 to 2.3) | 0.0005 |
| Hospitalisation for HF | |||
| Age >65 (yes-no) | 7 | 1.2 (1.1 to 2.3) | 0.007 |
| NYHA class III-IV vs I-II | 16 | 2.0 (1.4 to 2.9) | <0.0001 |
| Severe FMR (yes-no) | 8 | 1.7 (1.2 to 2.5) | 0.004 |
| RMP (yes-no) | 0.5 | 1.1 (0.8 to 1.6) | 0.5 |
| LVEF <30% (yes-no) | 1.4 | 1.2 (0.8 to 1.8) | 0.2 |
FMR, functional mitral regurgitation; HF, heart failure; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; RMP, restrictive mitral filling pattern.