Characteristics of patients with aortic stenosis and their two subgroups stratified according to the percentage of high molecular weight multimers (%HMWM) of von Willebrand factor
| All patients (n=53) | %HMWM <10.3 (n=11) | %HMWM >10.3 (n=42) | p Value | |
| Demographic and clinical data | ||||
| Age (years) | 65.6±10.7 | 65.6±12.1 | 65.21±11.3 | 0.83 |
| Male, n (%) | 35/66 | 10/91 | 25/60 | 0.03 |
| Body mass index (kg/m2) | 27.58±0.6 | 25.45±3.8 | 28.26±0.8 | 0.13 |
| Hypertension, n (%) | 38 (72) | 9 (82) | 29 (69) | 0.01 |
| Hypercholesterolaemia, n (%) | 25 (47) | 6 (55) | 19 (45) | 0.07 |
| Current smoking, n (%) | 25 (47) | 7 (64) | 18 (43) | 0.04 |
| Echocardiography | ||||
| Maximal gradient (mm Hg) | 88.15±22 | 102.67±24.2 | 75.66±12.7 | 0.0003 |
| Mean gradient (mm Hg) | 63.65±16.3 | 79.45±17.5 | 54.85±12.1 | 0.0002 |
| LVEF (%) | 62.22±11.1 | 61.70±9.3 | 62.12±2.2 | 0.86 |
| AVA (cm2) | 0.69±0.3 | 0.61±0.2 | 0.71±0.05 | 0.35 |
| AVAI (cm2/m2) | 0.37±0.02 | 0.33±0.08 | 0.37±0.1 | 0.38 |
| Laboratory parameters | ||||
| Glucose (mmol/l) | 5.79±1.4 | 6.03±1.6 | 5.78±1.5 | 0.07 |
| Creatinine (μmol/l) | 75.79 (57.3–121.4) | 76.62 (57.3–114.4) | 74.67 (57.6–121.4) | 0.07 |
| Total cholesterol (mmol/l) | 4.76±1.06 | 4.59±0.9 | 4.89±1.1 | 0.87 |
| HDL cholesterol (mmol/l) | 1.36±0.4 | 1.40±0.3 | 1.34±0.4 | 0.96 |
| LDL cholesterol (mmol/l) | 3.07±1.03 | 3.14±1 3 | 0.02±1.1 | 0.68 |
| Triglycerides (mmol/l) | 1.48±0.6 | 1.56±0.7 | 1.42±0.5 | 0.14 |
| Platelets (×103/mm3) | 256.81±53.9 | 231.59±55.7 | 267.14±48.9 | 0.09 |
| hsCRP (mg/l) | 4.43 (0.55–18.47) | 4.53 (0.55–18.47) | 4.32 (1.08–12.9) | 0.28 |
| Interleukin 6 (ng/ml) | 3.61 (0.3–10.13) | 3.45 (0.56–10.13) | 3.57 (0.3–9.99) | 0.79 |
Data are given as mean±SD, median (IQR) or n (%).
AVA, aortic valve area; AVAI, aortic valve area index; HDL, high-density lipoprotein; hsCRP, high-sensitivity C reactive protein; LDL, low-density lipoprotein; LVEF, left ventricular ejection fraction.