Table 2

Univariable and multivariable analysis of predictors of mortality and valve-related events

MortalityValve-related events
UnivariableMultivariableUnivariableMultivariable
HR (95% CI)p* ValueHR (95% CI)p* ValueHR (95% CI)p* ValueHR (95% CI)p* Value
Age (>75 years)2.18 (1.12 to 4.19)0.022.29 (1.16 to 4.49)0.021.13 (0.55 to 2.17)0.73
Male1.73 (0.90 to 3.33)0.101.49 (0.81 to 2.73)0.20
Very severe AS2.39 (1.25 to 4.66)<0.012.57 (1.31 to 5.16)<0.013.79 (2.03 to 7.40)<0.0012.91 (1.54 to 5.79)<0.001
 Peak jet velocity (≥5.0 m/s)2.56 (1.28 to 4.91)0.123.07 (1.64 to 5.63)0.02
 MPG (≥50 mm Hg)2.07 (0.99 to 4.20)0.053.66 (1.90 to 7.18)<0.001
 Aortic valve area (<0.6 cm2)3.27 (1.69 to 6.25)<0.0013.70 (2.00 to 6.79)<0.001
Symptom2.66 (1.33 to 5.79)<0.012.93 (1.42 to 6.50)<0.014.11 (2.04 to 9.19)<0.0013.06 (1.50 to 6.93)0.002
Delayed aortic valve surgery0.48 (0.23 to 0.96)0.040.36 (0.16 to 0.73)<0.010.99 (0.54 to 1.86)0.97
Ischaemic heart disease1.23 (0.53 to 2.58)0.611.08 (0.47 to 2.23)0.84
  • * Cox proportional hazard model analysis.

  • AS, aortic stenosis; MPG, mean pressure gradient.