Univariable and multivariable analysis of predictors of mortality and valve-related events
| Mortality | Valve-related events | |||||||
| Univariable | Multivariable | Univariable | Multivariable | |||||
| HR (95% CI) | p* Value | HR (95% CI) | p* Value | HR (95% CI) | p* Value | HR (95% CI) | p* Value | |
| Age (>75 years) | 2.18 (1.12 to 4.19) | 0.02 | 2.29 (1.16 to 4.49) | 0.02 | 1.13 (0.55 to 2.17) | 0.73 | – | – |
| Male | 1.73 (0.90 to 3.33) | 0.10 | – | – | 1.49 (0.81 to 2.73) | 0.20 | – | – |
| Very severe AS | 2.39 (1.25 to 4.66) | <0.01 | 2.57 (1.31 to 5.16) | <0.01 | 3.79 (2.03 to 7.40) | <0.001 | 2.91 (1.54 to 5.79) | <0.001 |
| Peak jet velocity (≥5.0 m/s) | 2.56 (1.28 to 4.91) | 0.12 | – | – | 3.07 (1.64 to 5.63) | 0.02 | – | – |
| MPG (≥50 mm Hg) | 2.07 (0.99 to 4.20) | 0.05 | – | – | 3.66 (1.90 to 7.18) | <0.001 | – | – |
| Aortic valve area (<0.6 cm2) | 3.27 (1.69 to 6.25) | <0.001 | – | – | 3.70 (2.00 to 6.79) | <0.001 | – | – |
| Symptom | 2.66 (1.33 to 5.79) | <0.01 | 2.93 (1.42 to 6.50) | <0.01 | 4.11 (2.04 to 9.19) | <0.001 | 3.06 (1.50 to 6.93) | 0.002 |
| Delayed aortic valve surgery | 0.48 (0.23 to 0.96) | 0.04 | 0.36 (0.16 to 0.73) | <0.01 | 0.99 (0.54 to 1.86) | 0.97 | – | – |
| Ischaemic heart disease | 1.23 (0.53 to 2.58) | 0.61 | – | – | 1.08 (0.47 to 2.23) | 0.84 | – | – |
↵* Cox proportional hazard model analysis.
AS, aortic stenosis; MPG, mean pressure gradient.