General study characteristics and the estimated added predictive value of flow mediated dilation on top of traditional risk factor assessment
| First author | Year | Region | N | Mean age (years) | % Men | FU (years) | Definition marker | Endpoint | Event rate (%) | C-statistic without FMD | C-statistic with FMD | NRI (%)* |
| Yeboah21 | 2007 | USA | 2792 | 79 | 41 | 5 | % change in arterial diameter 2 min after cuff deflation and baseline | CVD† | 24.1 | 0.65 | 0.66 | – |
| Yeboah11 | 2009 | USA | 3026 | 61 | 50 | 5 | % change in arterial diameter 2 min after cuff deflation and baseline | CVD† | 6.0 | 0.74 | 0.74 | 29 |
The baseline prediction model used in each of the studies is described in supplementary table 1 (available online only).
↵* Intermediate risk was defined as an absolute predicted 5 year risk between 4% and 7.5%.11
↵† Non-fatal and fatal events.
CVD, cardiovascular disease; FMD, flow mediated dilation; FU, follow-up; NRI, net reclassification improvement.