Baseline characteristics according to age study groups
| Variable | Age category | p Value | ||
| <65 years (n=2807) | 65–74 years (n=1821) | ≥75 years (n=839) | ||
| Demographics | ||||
| Age (years) | 57 (51–60) | 69 (67–72) | 76 (75–78) | – |
| Body mass index | 27.6 (4.3) | 27.1 (3.9) | 26.0 (3.5) | <0.001 |
| Male gender | 2020 (72.0%) | 1163 (63.9%) | 533 (63.5%) | <0.001 |
| Clinical history | ||||
| Myocardial infarction | 563 (20.1%) | 468 (26.7%) | 276 (32.9%) | <0.001 |
| Percutaneous coronary intervention | 173 (6.2%) | 104 (5.7%) | 36 (4.3%) | 0.053 |
| Coronary artery bypass grafting | 40 (1.4%) | 52 (2.9%) | 22 (2.6%) | 0.003 |
| Risk factors | ||||
| Current cigarette smoking | 1307 (46.6%) | 417 (22.9%) | 99 (11.8%) | <0.001 |
| Hypertension | 759 (27.0%) | 755 (41.5%) | 327 (39.0%) | <0.001 |
| Hypercholesterolaemia | 695 (24.8%) | 431 (23.7%) | 132 (15.7%) | <0.001 |
| Diabetes | 295 (10.5%) | 290 (15.9%) | 124 (14.8%) | <0.001 |
| ST segment depression ≥0.1 mV | 1019 (36.8%) | 835 (46.2%) | 471 (57.0%) | <0.001 |
| FIR risk score | 2 (1–4) | 5 (4–7) | 8 (7–10) | – |
| FIR risk score (excluding age) | 2 (1–3) | 3 (1–5) | 3 (2–5) | <0.001 |
| Study | <0.001 | |||
| FRISC II | 1124 (40.0%) | 872 (47.9%) | 461 (54.9%) | |
| ICTUS | 671 (23.9%) | 377 (20.7%) | 152 (18.1%) | |
| RITA-3 | 1012 (36%.1) | 572 (31.4%) | 226 (26.9%) | |
Data are number (%), mean (SD) or median (25th–75th percentile). Normally distributed continuous variables were compared with the Student t test, skewed distributed with the Wilcoxon rank-sum test. Categorical variables were compared with the χ2 test in case of the variable study and with a test for linear trend for the other variables.
FIR risk score calculated as: age <60 years=0, 60–64 years=1, 65–69 years=2, 70–74 years=3, ≥75 years=5; diabetes=4; hypertension=1; ST segment depression=2; body mass index <25 kg/m2=1, 25–<35 kg/m2=0, ≥35 kg/m2=2.
FIR, FRISC II–ICTUS–RITA-3 trials.