Summary of outcomes of studies
| Studies (Year) | Mortality (%) | MACE (%) | Major bleeding | Access site complications | Other outcomes | ||||
| Radial | Femoral | Radial | Femoral | Radial | Femoral | Radial | Femoral | ||
| TEMPURA (2003) | 4/77 (5.2%) (NS) | 6/72 (8.3%) | 4/77 (17.8%) (NS) | 6/72 (8.3%) | 0/77 (0%) (NS) | 2/72 (3.0%) | Not available | Procedure time shorter in radial group (mean 44 vs 51 min; p<0.05). Cost of admission, length of stay and crossover not significantly different between 2 arms. | |
| RADIAL-AMI (2005) | 0/25 (0%) (NS) | 1/25 (4.0%) | 0/25 (0%) (NS) | 1/25 (4.0%) | 0/25 (0%) (NS) | 0/25 (0%) | 2/25 (8%) (NS) | 5/25 (20%) | No differences in quality of life measures using SF-36 acute survey. Radial crossover rate 4%, femoral 1% (NS) |
| FARMI (2007) | 3/57 (5.3%) (NS) | 3/57 (5.3%) | 3/57 (5.3%) (NS) | 3/57 (5.3%) | 3/57 (5.3%) (NS) | 3/57 (5.3%) | 8/57 (14%) (p=0.014) | 20/57 (35.1%) | Crossover 12.3% radial vs 1.8% femoral (p=0.03). Fluoroscopy duration mean 13 vs 8 min in radial and femoral respectively (p<0.01) |
| Yan et al (2008) | 3/57 (5.3%) (NS) | 3/46 (6.5%) | 3/57 (5.3%) (NS) | 3/46 (6.5%) | 0/57 (0%) (NS) | 1/46 (2.2%) | 1/57 (1.8%) (p<0.01) | 6/46 (13.1%) | Hospital stay shorter in radial group (p<0.01; mean 7 vs 10 days). Time to reperfusion, procedural time and procedural success similar in both groups. |
| RADIAMI (2009) | 0/50 (0%) (NS) | 1/50 (2%) | 3/50 (6%) (NS) | 4/50 (8%) | 3/50 (6%) (NS) | 7/50 (14%) | Not available | Mean door to balloon time longer in radial group (64.6 vs 76.9 min; p=0.02) | |
| Gan et al (2009) | 2/90 (2.2%) (NS) | 3/105 (2.9%) | 2/90 (2.2%) (NS) | 5/105 (4.8%) | 0/90 (0%) (NS) | 2/105 (1.9%) | 2/90 (2.2%) p<0.05 | 12/105 (11.4%) | Mean procedure time longer in radial arm (mean 29 vs 27 min p<0.05) |
| Hou et al (2010) | 4/100 (4%) (NS) | 5/100 (5%) | 4/100 (4%) (NS) | 5/100 (5%) | 0/100 (0%) | 3/100 (3%) | Not available | Puncture time, procedural time, reperfusion time and fluoroscopy time all similar in both groups. | |
| RIVAL (2011) | 12/955 (1.3%) p=0.006 | 32/1003 (3.2%) | 26/955 (2.7%) p=0.03 | 46/1003 (4.6%) | 8/955 (0.8%) (NS) | 9/1003 (0.9%) | 12/955 (1.3%) p=0.002 | 35/1003 (3.5%) | Access site crossover 5.3 vs 1.6% in radial and femoral groups respectively (p<0.0001) |
| RADIAMI II (2011) | 0/49 | 0/59 (0%) | 1/49 (2.1%) | 1/59 (1.7%) | 4/49 (8.2%) | 6/59 (10.2%) | Not available | Procedure time similar but door to balloon time 64.6 vs 76.9 min (means; p<0.05) | |