Effect of change in serial midregional proatrial natriuretic peptide (MR-proANP) and C-terminal provasopressin (copeptin) concentrations over the study period on outcome of death/cardiac transplantation
| Variable | HR (95% CI) | p Value | C-Statistic |
| Normal to raised MR-proANP | 4.35 (0.61 to 31.02) | 0.143 | 0.641 |
| Raised MR-proANP to <30% change (increase or decrease but none back to normal value) | 5.79 (1.38 to 24.30) | 0.016 | |
| Raised MR-proANP to ≥30% further increase in MR-proANP | 10.07 (2.34 to 43.38) | 0.002 | |
| Normal to raised copeptin | 4.11 (0.68 to 24.61) | 0.122 | 0.684 |
| Raised copeptin to <30% change (increase or decrease but none back to normal value) | 4.20 (0.95 to 18.47) | 0.058 | |
| Raised copeptin to ≥30% further increase in copeptin | 11.48 (2.74 to 48.08) | <0.001 |
All values are relative to normal values remaining. CI, confidence interval; HR, hazard ratio; MR-proANP, mid-regional proatrial natriuretic peptide.