Diagnostic performance of copeptin and different troponin assays and their combination at presentation in patients with and without pre-existing coronary artery disease (CAD)
| Sensitivity (95% CI) | Specificity (95% CI) | Negative predictive value (95% CI) | Positive predictive value (95% CI) | |
| Patients with pre-existing CAD | ||||
| Copeptin 9 pmol/l (cut-off) | 75.6 (64.6 to 84.7) | 56.3 (51.0 to 61.6) | 91.3 (86.8 to 94.7) | 27.6 (21.7 to 34.1) |
| Roche troponin T fourth generation (cTnT) | ||||
| cTnT 0.01 μg/l (cut-off) | 78.2 (67.4 to 86.8) | 90.1 (86.6 to 93.0) | 95.0 (92.1 to 97.0) | 63.5 (53.1 to 73.1) |
| + Copeptin 9 pmol/l (cut-off) | 98.7 (93.0 to 99.8) | 53.5 (48.2 to 58.8) | 99.5 (97.1 to 99.9) | 31.8 (26.0 to 38.1) |
| Roche high-sensitive troponin T (hs-cTnT) | ||||
| hs-cTnT 0.014 μg/l (cut-off) | 93.6 (85.7 to 97.9) | 60.2 (55.0 to 65.4) | 97.7 (94.8 to 99.3) | 34.1 (27.8 to 40.9) |
| + Copeptin 9 pmol/l (cut-off) | 98.7 (93.0 to 99.8) | 41.4 (36.2 to 46.7) | 99.3 (96.3 to 99.9) | 27.0 (22.0 to 32.6) |
| Patients without pre-existing CAD | ||||
| Copeptin 9 pmol/l (cut-off) | 67.9 (58.2 to 76.7) | 69.4 (65.7 to 73.0) | 92.8 (90.1 to 95.0) | 27.2 (21.9 to 33.0) |
| Roche troponin T fourth generation (cTnT) | ||||
| cTnT 0.01 μg/l (cut-off) | 83.0 (74.5 to 89.6) | 94.6 (92.6 to 96.2) | 97.1 (95.4 to 98.3) | 72.1 (63.3 to 79.9) |
| + Copeptin 9 pmol/l (cut-off) | 98.1 (93.3 to 99.7) | 66.9 (63.1 to 70.5) | 99.5 (98.3 to 99.9) | 33.2 (28.0 to 38.8) |
| Roche high-sensitive troponin T (hs-cTnT) | ||||
| hs-cTnT 0.014 μg/l (cut-off) | 94.3 (88.1 to 97.9) | 81.8 (78.5 to 84.7) | 98.9 (97.5 to 99.6) | 46.5 (39.7 to 52.4) |
| + Copeptin 9 pmol/l (cut-off) | 99.1 (94.8 to 99.8) | 60.1 (56.1 to 63.9) | 99.7 (98.5 to 100.0) | 29.4 (24.7 to 34.4) |