Independent predictors of higher circulating osteoprotegerin (tertile 3) at baseline
| Variable | OR (95% CI) | p Value |
| Age (>75 years) | 2.18 (1.76 to 2.72) | <0.001 |
| Creatinine clearance <60 ml/min | 1.80 (1.46 to 2.23) | <0.001 |
| Baseline BNP (>80 ng/l) | 1.60 (1.36 to 1.89) | <0.001 |
| History of hypercholesterolaemia (yes) | 0.70 (0.59 to 0.82) | <0.001 |
| History of diabetes (yes) | 2.04 (1.73 to 2.41) | <0.001 |
| History of heart failure (yes) | 1.46 (1.19 to 1.80) | <0.001 |
| Gender (males) | 0.76 (0.64 to 0.89) | 0.001 |
| Region: Eastern Europe (referent North America) | 0.74 (0.59 to 0.93) | 0.010 |
| Region: Western Europe (referent North America) | 1.33 (1.08 to 1.63) | 0.006 |
| Index event NSTEMI (referent UA) | 1.34 (1.10 to 1.62) | 0.003 |
| Family history of CAD | 0.83 (0.70 to 0.97) | 0.021 |
| TnI ultra positive (≥40 ng/l) | 1.24 (1.01 to 1.53) | 0.042 |
BNP, B type natriuretic peptide; CAD, coronary artery disease; NSTEMI, non-ST elevation myocardial infarction; TnI, troponin I; UA, unstable angina.