Table 2

Cardiovascular disease (CVD) risk classification comparing the ADVANCE CVD prediction model with an extended model which added estimated glomerular filtration rate

Extended model categories	ADVANCE model risk categories for major CVD
Extended model categories	<2.4%	2.4% to <8%	≥8%	Total
Participants with an event
<2.4%	21	1	0	22
2.4% to <8%	0	201	2	203
≥8%	0	2	202	204
Subtotal	21	204	204	429
Participants without an event
<2.4%	973	50	0	1023
2.4% to <8%	37	4276	32	4345
≥8%	0	29	1342	1371
Subtotal	1010	4355	1374	6739

To compute the net reclassification improvement, participants were a priori divided into three risk categories: 0% to <2.4%, 2.4% to <8% and ≥8% 4-year predicted probability of major CVD, which extrapolated to predicted 10-year risk groups of <5%, 5–20% and ≥20%, respectively.