Table 2

Confirmed and suspected factors leading to increased PVR in COPD101

Factors affecting PH in COPDImpact on pulmonary vessels
Airflow limitationPressure swings
EmphysemaReduction of vascular bed
Alveolar hypoxiaVasoconstriction/remodelling
Hypercapnic acidosisVasoconstriction
PolycythaemiaHyperviscosity
Lung/systemic inflammationRemodelling, including fibrosis
  • COPD, chronic obstructive pulmonary disease; PH, pulmonary hypertension.